Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt..
Acta Biomed. 2021 Sep 2;92(4):e2021255. doi: 10.23750/abm.v92i4.11613.
Hormone resistance is defined as a reduced or absence of target tissues responsiveness to a hormone, where the presentation is related to either a relative lack or excess of hormones. Various disorders of hormone resistance were encountered including, Laron syndrome, nephrogenic diabetes insipidus, thyroid hormone resistance syndrome, pseudohypoparathyroidism, insulin resistance, familial glucocorticoid deficiency, pseudohypoaldosteronism, X linked hypophosphatemic rickets and androgen insensitivity syndrome. The article gives a summary that presents, in concentrated form, what the primary care physicians need to know about recognition, clinical presentation, diagnosis, and management of various hormone resistance in children.
激素抵抗定义为靶组织对激素的反应性降低或缺失，其表现与激素相对缺乏或过多有关。我们遇到了各种激素抵抗疾病，包括 Laron 综合征、肾性尿崩症、甲状腺激素抵抗综合征、假性甲状旁腺功能减退症、胰岛素抵抗、家族性糖皮质激素缺乏症、假性醛固酮血症、X 连锁低磷佝偻病和雄激素不敏感综合征。本文总结了初级保健医生需要了解的关于儿童各种激素抵抗的识别、临床表现、诊断和管理的知识。
