University of Udine.
Acta Biomed. 2021 Sep 2;92(4):e2021101. doi: 10.23750/abm.v92i4.11478.
COVID-19 infection has several cardiovascular implications, and coagulopathy is a common abnormality in these patients, often coupled with elevated plasma fibrinogen and D-dimer levels, contributing to adverse outcomes. Phlegmasia cerulea dolens (PCD) is a rare manifestation of deep vein thrombosis. It is life-threatening and can rapidly lead to venous gangrene of the extremity. Only a few cases of COVID-19 associated with PCD are reported in the literature, despite thromboembolism being the common paradigm between the two diseases. We present the case of a 64-year-old adult with acute severe COVID-19 pneumonia who developed PCD despite constantly elevated activated partial thromboplastin time and international normalized ratio.
COVID-19 感染有多种心血管影响，凝血功能障碍是这些患者的常见异常，常伴有血浆纤维蛋白原和 D-二聚体水平升高，导致不良后果。苍白色萎缩（PCD）是深静脉血栓形成的一种罕见表现。它具有致命性，并可迅速导致肢体静脉坏疽。尽管血栓栓塞是这两种疾病的共同模式，但文献中仅报道了少数几例与 COVID-19 相关的 PCD 病例。我们报告了一例 64 岁成人急性重症 COVID-19 肺炎患者，尽管持续升高的活化部分凝血活酶时间和国际标准化比值，但仍发生 PCD。
