Aarntzen Erik H J G, Noriega-Álvarez Edel, Artiko Vera, Dias André H, Gheysens Olivier, Glaudemans Andor W J M, Lauri Chiara, Treglia Giorgio, van den Wyngaert Tim, van Leeuwen Fijs W B, Terry Samantha Y A
Inflammation and Infection Committee EANM, Vienna, Austria.
Department of Medical Imaging, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
EJNMMI Res. 2021 Sep 6;11(1):85. doi: 10.1186/s13550-021-00820-8.
Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the pathogenesis of inflammatory musculoskeletal diseases is, to a large extent, derived from preclinical and basic research experiments. In vivo molecular imaging enables us to study molecular targets and to measure biochemical processes non-invasively and longitudinally, providing information on disease processes and potential therapeutic strategies, e.g. efficacy of novel therapeutic interventions, which is of complementary value next to ex vivo (post mortem) histopathological analysis and molecular assays. Remarkably, the large body of preclinical imaging studies in inflammatory musculoskeletal disease is in contrast with the limited reports on molecular imaging in clinical practice and clinical guidelines. Therefore, in this EANM-endorsed position paper, we performed a systematic review of the preclinical studies in inflammatory musculoskeletal diseases that involve radionuclide imaging, with a detailed description of the animal models used. From these reflections, we provide recommendations on what future studies in this field should encompass to facilitate a greater impact of radionuclide imaging techniques on the translation to clinical settings.
炎性肌肉骨骼疾病是一组慢性致残性疾病，由遗传和环境因素之间的复杂相互作用演变而来，这些因素会导致先天性和适应性免疫反应紊乱。炎性肌肉骨骼疾病发病机制的理解在很大程度上源于临床前和基础研究实验。体内分子成像使我们能够研究分子靶点，并以非侵入性和纵向方式测量生化过程，提供有关疾病过程和潜在治疗策略的信息，例如新型治疗干预措施的疗效，这在体外（尸检）组织病理学分析和分子检测之外具有补充价值。值得注意的是，炎性肌肉骨骼疾病的大量临床前成像研究与临床实践和临床指南中关于分子成像的有限报告形成对比。因此，在这份欧洲核医学协会认可的立场文件中，我们对涉及放射性核素成像的炎性肌肉骨骼疾病临床前研究进行了系统综述，并详细描述了所使用的动物模型。基于这些思考，我们就该领域未来的研究应涵盖哪些内容提出建议，以促进放射性核素成像技术在向临床应用转化方面产生更大影响。
