miR-10b-5p 通过下调 Tiam1 抑制胃癌移植瘤小鼠模型的肿瘤生成。
MiR-10b-5p inhibits tumorigenesis in gastric cancer xenograft mice model through down-regulating Tiam1.
机构信息
Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China.
出版信息
Exp Cell Res. 2021 Oct 15;407(2):112810. doi: 10.1016/j.yexcr.2021.112810. Epub 2021 Sep 4.
The miR-10b-5p plays an important role in gastric cancer development but its exact effect on gastric cancer development in vivo has not been fully studied. We showed that miR-10b-5p inhibited the proliferation and migration of gastric cancer cells by down-regulating Tiam1 which was up-regulated in both gastric cancer cells and tissues. Gastric cancer xenograft experiment showed that lenti-miR-10b-5p treatment and agomir-10b-5p injection could significantly retard tumor growth and reduce tumor size and induced apoptosis. Therefore, our results elucidate the tumor suppressor role of miR-10b-5p in gastric cancer in which it acts as a negative regulator of Tiam1 and also provide a molecular mechanism for agomir-10b-5p to treat gastric cancer.
miR-10b-5p 在胃癌发展中起着重要作用，但它对体内胃癌发展的确切影响尚未得到充分研究。我们表明，miR-10b-5p 通过下调在胃癌细胞和组织中上调的 Tiam1 来抑制胃癌细胞的增殖和迁移。胃癌异种移植实验表明，lenti-miR-10b-5p 处理和 agomir-10b-5p 注射可显著延缓肿瘤生长，减少肿瘤大小并诱导细胞凋亡。因此，我们的结果阐明了 miR-10b-5p 在胃癌中的肿瘤抑制作用，它作为 Tiam1 的负调节剂，并为 agomir-10b-5p 治疗胃癌提供了分子机制。
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