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MCRS1表达调控肿瘤活性并影响胃癌患者的生存概率。

MCRS1 Expression Regulates Tumor Activity and Affects Survival Probability of Patients with Gastric Cancer.

作者信息

Wang Liang-Han, Chang Chih-Chun, Cheng Chiao-Yin, Liang Yao-Jen, Pei Dee, Sun Jen-Tang, Chen Yen-Lin

机构信息

Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei 220, Taiwan.

Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei 220, Taiwan.

出版信息

Diagnostics (Basel). 2022 Jun 20;12(6):1502. doi: 10.3390/diagnostics12061502.

DOI:10.3390/diagnostics12061502
PMID:35741311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9221628/
Abstract

Gastric cancer is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Surgery remains the first-choice treatment. Chemotherapy is considered in the middle and advanced stages, but has limited success. Microspherule protein 1 (MCRS1, also known as MSP58) is a protein originally identified in the nucleus and cytoplasm that is involved in the cell cycle. High expression of MCRS1 increases tumor growth, invasiveness, and metastasis. The mechanistic relationships between MCSR1 and proliferation, apoptosis, angiogenesis, and epithelial-mesenchymal transition (EMT) remain to be elucidated. We clarified these relationships using immunostaining of tumor tissues and normal tissues from patients with gastric cancer. High MCRS1 expression in gastric cancer positively correlated with Ki-67, Caspase3, CD31, Fibronectin, pAKT, and pAMPK. The hazard ratio of high MCRS1 expression was 2.44 times that of low MCRS1 expression, negatively impacting patient survival.

摘要

胃癌是全球第五大常见癌症，也是癌症相关死亡的第三大常见原因。手术仍然是首选治疗方法。化疗适用于中晚期，但成功率有限。微球蛋白1（MCRS1，也称为MSP58）是一种最初在细胞核和细胞质中发现的蛋白质，参与细胞周期。MCRS1的高表达会增加肿瘤生长、侵袭和转移。MCSR1与增殖、凋亡、血管生成和上皮-间质转化（EMT）之间的机制关系仍有待阐明。我们通过对胃癌患者的肿瘤组织和正常组织进行免疫染色来阐明这些关系。胃癌中MCRS1的高表达与Ki-67、Caspase3、CD31、纤连蛋白、pAKT和pAMPK呈正相关。MCRS1高表达的风险比是低表达的2.44倍，对患者生存产生负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/bfabb297c820/diagnostics-12-01502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/646f739cf270/diagnostics-12-01502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/1242b5d0b53e/diagnostics-12-01502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/31aec9f064f7/diagnostics-12-01502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/bfabb297c820/diagnostics-12-01502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/646f739cf270/diagnostics-12-01502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/1242b5d0b53e/diagnostics-12-01502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/31aec9f064f7/diagnostics-12-01502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f866/9221628/bfabb297c820/diagnostics-12-01502-g004.jpg

相似文献

[1]
MCRS1 Expression Regulates Tumor Activity and Affects Survival Probability of Patients with Gastric Cancer.

Diagnostics (Basel). 2022-6-20

[2]
MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer.

Mol Cancer. 2014-11-6

[3]
Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase.

Cell Signal. 2019-4-3

[4]
Expression of MCRS1 and MCRS2 and their correlation with serum carcinoembryonic antigen in colorectal cancer.

Exp Ther Med. 2016-8

[5]
The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway.

J Exp Clin Cancer Res. 2015-10-14

[6]
Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.

J Biol Chem. 2005-11-25

[7]
Increased Expression of 58-kDa Microspherule Protein (MSP58) in Human Gastric Cancer Promotes Cell Proliferation and Correlates with Poor Patient Survival.

Clin Lab. 2016

[8]
The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.

Biochim Biophys Acta. 2013-1

[9]
Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.

Genes Chromosomes Cancer. 2012-12-8

[10]
The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.

Cell Cycle. 2023

本文引用的文献

[1]
High Mobility Group A 1 Expression as a Poor Prognostic Marker Associated with Tumor Invasiveness in Gastric Cancer.

Life (Basel). 2022-5-9

[2]
Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278.

J Clin Lab Anal. 2022-6

[3]
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.

J Cancer. 2021-11-8

[4]
MiR-10b-5p inhibits tumorigenesis in gastric cancer xenograft mice model through down-regulating Tiam1.

Exp Cell Res. 2021-10-15

[5]
Role of heparanase 2 (Hpa2) in gastric cancer.

Neoplasia. 2021-9

[6]
Inhibition of fibronectin accumulation suppresses tumor growth.

Neoplasia. 2021-9

[7]
Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation.

Front Cell Dev Biol. 2021-6-21

[8]
The Epithelial-to-Mesenchymal Transition (EMT) in Development and Cancer.

Annu Rev Cancer Biol. 2020-3

[9]
Oral glutamine inhibits tumor growth of gastric cancer bearing mice by improving immune function and activating apoptosis pathway.

Tissue Cell. 2021-8

[10]
CD31/PECAM-1 impacts engraftment, growth and spread of mantle cell lymphoma cells and positively correlates with extramedullary involvement.

Leuk Lymphoma. 2021-4

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