Ishii A I, Terada M, Sano M
Department of Parasitology, Hamamatsu University School of Medicine, Japan.
Southeast Asian J Trop Med Public Health. 1987 Dec;18(4):547-51.
The effects of neuropharmacological agents on the motility of irradiated and non-irradiated Angiostrongylus cantonensis adult females were studied. GABA induced complete paralysis in non-irradiated and 5,000 R-irradiated worms, but caused only slight paralysis on 10,000 R-irradiated worms. The paralytic effect of GABA was antagonised by picrotoxin. The reason for low susceptibility of heavily irradiated worms to GABA is not known. There was no difference in susceptibility of non-irradiated and irradiated worms to other neuropharmacological agents including eserine, phenylephrine and dibenamine.
研究了神经药理学药物对辐照和未辐照的广州管圆线虫成年雌虫运动能力的影响。γ-氨基丁酸（GABA）可使未辐照和接受5000拉德辐照的虫体完全麻痹，但对接受10000拉德辐照的虫体仅引起轻微麻痹。GABA的麻痹作用可被印防己毒素拮抗。重度辐照虫体对GABA敏感性低的原因尚不清楚。未辐照和辐照虫体对包括毒扁豆碱、去氧肾上腺素和苄胺唑啉在内的其他神经药理学药物的敏感性没有差异。
