National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; Department of Psychiatry, The Third People's Hospital of Foshan, Foshan 528000, Guangdong, China.
J Affect Disord. 2021 Dec 1;295:339-346. doi: 10.1016/j.jad.2021.08.082. Epub 2021 Aug 31.
Whether premenstrual dysphoric disorder (PMDD) is correlated with the risk of suicidality and the extent of its effect on suicidality are unclear. The present study was conducted to elucidate the association between PMDD and suicidality from relevant studies.
Four electronic databases, namely, Scopus, Embase, PubMed, and Web of Science, were searched from inception to November 15, 2020. Quality assessment, data synthesis, and sensitivity analysis were performed on the included studies.
Six studies with 8 532 participants were included in this meta-analysis. PMDD was associated with an increased risk of suicidal ideation (odds ratio [OR]=2.34, 95% confidence interval [CI]=1.50-3.18, I=0.0%, p=0.99, k=4). Patients with PMDD had a greater risk of experiencing suicide attempt (OR=2.13, 95% CI=1.05-3.21, I=0.0%, p=0.81, k=5). PMDD was associated with an increased risk of suicidal plan (OR=2.24, 95% CI=1.03-3.45, I=0.0%, p=0.96, k=2).
The diagnosis of PMDD should be considered "provisional" in all the included studies.
Among PMDD sufferers there would be a group of particularly suicidal women. Clinicians who treat patients with PMDD should be vigilant for signs of suicidal ideation and behavior to implement better treatment and preventive measures.
经前期烦躁障碍（PMDD）与自杀风险是否相关及其对自杀风险的影响程度尚不清楚。本研究旨在从相关研究中阐明 PMDD 与自杀之间的关联。
从建库至 2020 年 11 月 15 日，检索了 Scopus、Embase、PubMed 和 Web of Science 这四个电子数据库。对纳入的研究进行质量评估、数据综合和敏感性分析。
本荟萃分析纳入了 6 项研究，共 8532 名参与者。PMDD 与自杀意念风险增加相关（比值比 [OR]=2.34，95%置信区间 [CI]=1.50-3.18，I=0.0%，p=0.99，k=4）。患有 PMDD 的患者自杀未遂的风险更高（OR=2.13，95%CI=1.05-3.21，I=0.0%，p=0.81，k=5）。PMDD 与自杀计划风险增加相关（OR=2.24，95%CI=1.03-3.45，I=0.0%，p=0.96，k=2）。
所有纳入的研究都应将 PMDD 的诊断视为“暂定”。
在 PMDD 患者中，会有一部分女性特别具有自杀倾向。治疗 PMDD 患者的临床医生应警惕自杀意念和行为的迹象，以实施更好的治疗和预防措施。
