Gargano Giuseppe, Oliva Francesco, Migliorini Filippo, Maffulli Nicola
Department of Trauma and Orthopaedic Surgery, AOU San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, 84131, Salerno, Italy; Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 7, Baronissi, SA, Italy.
Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University Hospital, 52074 Aachen, Germany.
Surgeon. 2022 Dec;20(6):e315-e321. doi: 10.1016/j.surge.2021.07.008. Epub 2021 Sep 3.
Adolescent idiopathic scoliosis (AIS) is a multifactorial condition with genetic predisposing factors, and several causes have been put forward for its aetiopathogenesis, including possible hormonal dysfunction. Melatonin seems to play significant role in AIS.
A systematic search in different database, to July 2021, was performed to define the role of melatonin in the pathophysiology of adolescent idiopathic scoliosis. Eight suitable studies were identified.
The concentration and rhythm of melatonin secretion can play an important role by influencing the pathogenesis of adolescent idiopathic scoliosis.
Although there are many alterations of melatonin in subjects with adolescent idiopathic scoliosis, the many variables present do not allow to establish a direct cause-effect relationship.
Level IV.
青少年特发性脊柱侧凸（AIS）是一种具有遗传易感性因素的多因素疾病，其发病机制已提出多种原因，包括可能的激素功能障碍。褪黑素似乎在AIS中起重要作用。
截至2021年7月，在不同数据库中进行了系统检索，以确定褪黑素在青少年特发性脊柱侧凸病理生理学中的作用。共确定了八项合适的研究。
褪黑素分泌的浓度和节律可通过影响青少年特发性脊柱侧凸的发病机制发挥重要作用。
虽然青少年特发性脊柱侧凸患者存在许多褪黑素改变，但由于存在众多变量，无法建立直接的因果关系。
四级。
