Department of Cardiology, Huaihua First People's Hospital, Huaihua, China.
Department of Neurology, Huaihua First People's Hospital, Huaihua, China.
Front Endocrinol (Lausanne). 2021 Aug 17;12:731273. doi: 10.3389/fendo.2021.731273. eCollection 2021.
Vascular aging is characterized by alterations in the constitutive properties and biological functions of the blood vessel wall. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are indispensability elements in the inner layer and the medial layer of the blood vessel wall, respectively. Dipeptidyl peptidase-4 (DPP4) inhibitors, as a hypoglycemic agent, play a protective role in reversing vascular aging regardless of their effects in meliorating glycemic control in humans and animal models of type 2 diabetes mellitus (T2DM) through complex cellular mechanisms, including improving EC dysfunction, promoting EC proliferation and migration, alleviating EC senescence, obstructing EC apoptosis, suppressing the proliferation and migration of VSMCs, increasing circulating endothelial progenitor cell (EPC) levels, and preventing the infiltration of mononuclear macrophages. All of these showed that DPP4 inhibitors may exert a positive effect against vascular aging, thereby preventing vascular aging-related diseases. In the current review, we will summarize the cellular mechanism of DPP4 inhibitors regulating vascular aging; moreover, we also intend to compile the roles and the promising therapeutic application of DPP4 inhibitors in vascular aging-related diseases.
血管衰老的特征是血管壁的固有特性和生物学功能发生改变。内皮细胞（ECs）和血管平滑肌细胞（VSMCs）分别是血管壁内层和中层不可或缺的组成部分。二肽基肽酶-4（DPP4）抑制剂作为一种降糖药，通过复杂的细胞机制，在改善血糖控制方面发挥保护作用，可逆转血管衰老，无论在 2 型糖尿病（T2DM）患者还是动物模型中都是如此，这些机制包括改善 EC 功能障碍、促进 EC 增殖和迁移、减轻 EC 衰老、阻止 EC 凋亡、抑制 VSMC 的增殖和迁移、增加循环内皮祖细胞（EPC）水平以及防止单核巨噬细胞浸润。所有这些都表明，DPP4 抑制剂可能对血管衰老产生积极影响，从而预防与血管衰老相关的疾病。在本综述中，我们将总结 DPP4 抑制剂调节血管衰老的细胞机制；此外，我们还打算汇编 DPP4 抑制剂在血管衰老相关疾病中的作用和有前途的治疗应用。
