Martinez Marc, Rathod Sandeep, Friesen Hunter J, Rosen John M, Friesen Craig A, Schurman Jennifer V
Kansas City University of Medicine and Biosciences, Kansas City, MO, United States.
University of Kansas School of Medicine, Kansas City, MO, United States.
Front Pediatr. 2021 Aug 19;9:709326. doi: 10.3389/fped.2021.709326. eCollection 2021.
Rumination syndrome involves recurrent regurgitation of food and is believed to be underdiagnosed with patients experiencing long delays in diagnosis. It can be associated with significant social consequences, high rates of school absenteeism, and medical complications such as weight loss. The primary aims of the current review are to assess the literature regarding prevalence, pathophysiology, and treatment outcomes with a focus on neurotypical children and adolescents. Population studies in children/adolescents, 5 years of age or older, range from 0 to 5.1%. There are fewer studies in clinical settings, but the prevalence appears to be higher in patients with other gastrointestinal symptoms, particularly chronic vomiting. While physiologic changes that occur during a rumination episode are well-described, the underlying cause is less well-defined. In general, rumination appears to have similarities to other functional gastrointestinal disorders including dysmotility, possibly inflammation, and an interaction with psychologic function. While diaphragmatic breathing is considered the mainstay of treatment, pediatric data demonstrating efficacy is lacking, especially as an isolated treatment. Pediatric rumination syndrome remains greatly understudied, particularly regarding treatment. There is a need to better define prevalence in both the primary care and subspecialty clinical settings, especially in patients presenting with vomiting or apparent gastroesophageal reflux. There is a need to determine whether treatment of co-morbid conditions results in improvement of rumination. Diaphragmatic breathing needs to be studied and compared to other competing responses.
反刍综合征涉及食物的反复反流,据信其诊断不足,患者往往要经历长时间的诊断延迟。它可能会带来严重的社会后果、高缺勤率以及诸如体重减轻等医学并发症。本综述的主要目的是评估关于患病率、病理生理学和治疗结果的文献,重点关注发育正常的儿童和青少年。针对5岁及以上儿童/青少年的人群研究显示患病率在0%至5.1%之间。临床研究较少,但在有其他胃肠道症状的患者中,尤其是慢性呕吐患者,患病率似乎更高。虽然反刍发作期间发生的生理变化已有详细描述,但其根本原因仍不太明确。一般来说,反刍似乎与其他功能性胃肠疾病有相似之处,包括动力障碍、可能的炎症以及与心理功能的相互作用。虽然膈式呼吸被认为是主要治疗方法,但缺乏证明其疗效的儿科数据,尤其是作为单一治疗方法时。儿科反刍综合征的研究仍然非常不足,尤其是在治疗方面。有必要在初级保健和专科临床环境中更好地确定患病率,特别是在出现呕吐或明显胃食管反流的患者中。有必要确定合并症的治疗是否能改善反刍症状。需要对膈式呼吸进行研究并与其他竞争性反应进行比较。