Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, The Netherlands; Amsterdam UMC, University of Amsterdam, Clinical Epidemiology, Bioinformatics and Biostatistics, Amsterdam, The Netherlands.
Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, The Netherlands.
J Pediatr. 2020 Jun;221:107-114. doi: 10.1016/j.jpeds.2020.02.076.
To assess the prevalence of functional gastrointestinal disorders (FGIDs) in young children in a cross-sectional, multicenter study in Belgium, Italy, and The Netherlands.
Children were enrolled if they were age 0-48 months, attending a general pediatrician (Belgium, Italy) or a well-baby clinic (The Netherlands) for routine follow-up. Separate questionnaires were developed for infants age 0-12 months and for toddlers age 13-48 months. Questionnaires evaluated the clinical history, symptoms, sociodemographic information on the family, and exposure to stressful life events. FGIDs were defined according to Rome IV criteria.
In total 2751 children were included: 1698 infants age 0-12 months and 1053 children age 13-48 months. The prevalence of any FGID in infants age 0-12 months and 13-48 months was 24.7% and 11.3%, respectively. The most common disorders were infant regurgitation (13.8%) in infants and functional constipation (9.6%) in toddlers. Multivariable regression analyses demonstrated that younger age (P = .030) and formula feeding (P = .045) were associated with the prevalence of any FGID among infants. Country (Italy) (P = .033) and parents subjected to domestic violence (P = .035) were associated with the prevalence of any FGID in toddlers age 13-48 months.
FGIDs are common in a community sample of Western European infants and toddlers. Regurgitation is most prevalent in infants and functional constipation is most common in toddlers. Younger age, formula feeding, and domestic violence to parents are associated with the prevalence of FGIDs.
在比利时、意大利和荷兰进行的一项横断面、多中心研究中，评估婴幼儿功能性胃肠疾病（FGIDs）的患病率。
如果儿童年龄在 0-48 个月之间，正在接受普通儿科医生（比利时、意大利）或健康婴儿诊所（荷兰）的常规随访，则招募这些儿童。为 0-12 个月大的婴儿和 13-48 个月大的幼儿分别开发了单独的问卷。问卷评估了临床病史、症状、家庭的社会人口统计学信息以及暴露于压力生活事件。FGIDs 根据罗马 IV 标准定义。
共纳入 2751 名儿童：1698 名 0-12 个月大的婴儿和 1053 名 13-48 个月大的儿童。0-12 个月大婴儿和 13-48 个月大儿童任何 FGID 的患病率分别为 24.7%和 11.3%。最常见的疾病是婴儿反流（13.8%）和幼儿功能性便秘（9.6%）。多变量回归分析表明，年龄较小（P=0.030）和配方奶喂养（P=0.045）与婴儿 FGID 的患病率相关。国家（意大利）（P=0.033）和遭受家庭暴力的父母（P=0.035）与 13-48 个月大幼儿任何 FGID 的患病率相关。
FGIDs 在西欧婴幼儿的社区样本中很常见。反流在婴儿中最为常见，功能性便秘在幼儿中最为常见。年龄较小、配方奶喂养和父母遭受家庭暴力与 FGIDs 的患病率相关。
