College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Org Biomol Chem. 2021 Sep 29;19(37):8021-8024. doi: 10.1039/d1ob01477c.
Herein we describe a nickel-catalyzed remote hydrosilylation of unconjugated enones with bulky triphenylsilane. A range of -silyl enol ethers are obtained as major isomers due to the process of nickel triggered alkene isomerization. Notably, some specific alkyl silyl enol ethers can be prepared from this protocol, which are not easily accessed by the traditional strategy using a strong base and chlorosilane. This reaction features 100% atom economy, simple reaction conditions, and good yields.
在此，我们描述了镍催化的未共轭烯酮与体积庞大的三苯硅烷的远程硅氢化反应。由于镍引发的烯烃异构化过程，主要得到了-silyl 烯醇醚异构体。值得注意的是，通过该方法可以制备一些特定的烷基硅基烯醇醚，而这些化合物用传统的强碱和氯硅烷策略是难以制备的。该反应具有 100%的原子经济性、简单的反应条件和良好的收率。
