Li Jie, Qu Shuanglin, Zhao Wanxiang
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, P. R. China.
Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2360-2364. doi: 10.1002/anie.201913281. Epub 2019 Dec 20.
A rhodium-catalyzed remote C(sp )-H borylation of silyl enol ethers (SEEs, E/Z mixtures) by alkene isomerization and hydroboration is reported. The reaction exhibits mild reaction conditions and excellent functional-group tolerance. This method is compatible with an array of SEEs, including linear and branched SEEs derived from aldehydes and ketones, and provides direct access to a broad range of structurally diverse 1,n-borylethers in excellent regioselectivities and good yields. These compounds are precursors to various valuable chemicals, such as 1,n-diols and aminoalcohols.
报道了一种通过烯烃异构化和硼氢化实现铑催化的硅基烯醇醚（SEEs，E/Z混合物）远程C(sp) -H硼化反应。该反应具有温和的反应条件和出色的官能团耐受性。此方法适用于一系列SEEs，包括源自醛和酮的直链和支链SEEs，并能以优异的区域选择性和良好的产率直接合成多种结构多样的1,n-硼醚。这些化合物是各种有价值化学品的前体，如1,n-二醇和氨基醇。
