Molecular Biotechnology Platform, Public Center of Experimental Technology, School of Basic Medical Sciences, Southwest Medical University, Luzhou People's Republic of China.
Virulence. 2021 Dec;12(1):2314-2326. doi: 10.1080/21505594.2021.1963909.
To resolve the growing problem of drug resistance in the treatment of bacterial and fungal pathogens, specific cellular targets and pathways can be used as targets for new antimicrobial agents. Endogenous riboflavin biosynthesis is a conserved pathway that exists in most bacteria and fungi. In this review, the roles of endogenous and exogenous riboflavin in infectious disease as well as several antibacterial agents, which act as analogues of the riboflavin biosynthesis pathway, are summarized. In addition, the effects of exogenous riboflavin on immune cells, cytokines, and heat shock proteins are described. Moreover, the immune response of endogenous riboflavin metabolites in infectious diseases, recognized by MHC-related protein-1, and then presented to mucosal associated invariant T cells, is highlighted. This information will provide a strategy to identify novel drug targets as well as highlight the possible clinical use of riboflavin.
为了解决治疗细菌和真菌病原体时耐药性日益严重的问题，可以将特定的细胞靶标和途径作为新型抗菌药物的靶标。内源性核黄素生物合成是一种存在于大多数细菌和真菌中的保守途径。在这篇综述中，总结了内源性和外源性核黄素在传染病中的作用，以及几种作为核黄素生物合成途径类似物的抗菌药物。此外，还描述了外源性核黄素对免疫细胞、细胞因子和热休克蛋白的影响。此外，还强调了 MHC 相关蛋白-1识别的内源性核黄素代谢物在传染病中的免疫反应，然后将其呈递给黏膜相关不变 T 细胞。这些信息将为确定新的药物靶点提供策略，并强调核黄素的可能临床应用。
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