Institute of Modern Biopharmaceuticals, Ministry Key Laboratory of Education Eco-environment of Three Gorges, School of Life Sciences, Southwest University, Chongqing 400715, China.
Chem Biol Drug Des. 2010 Apr;75(4):339-47. doi: 10.1111/j.1747-0285.2010.00946.x. Epub 2010 Feb 8.
Riboflavin (vitamin B2) is the direct precursor of redox enzyme cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential for multiple cell physiology. The riboflavin biosynthetic pathway is regarded as a rich resource for therapeutic targets for broad spectrum antibiotics. Enzymatic pathways, regulatory factors of the riboflavin biosynthesis, and relevant drug discovery are summarized in this review. The novel riboswitch regulatory mechanism of riboflavin metabolism is also described. A compendium of chemical modulators of riboflavin biosynthesis and regulatory networks is listed and such demonstrates the promise of riboflavin biosynthesis and regulatory mechanisms as potential therapeutic targets for novel antibiotic drug discovery.
核黄素（维生素 B2）是氧化还原酶辅因子黄素单核苷酸（FMN）和黄素腺嘌呤二核苷酸（FAD）的直接前体，这两种物质对多种细胞生理功能至关重要。核黄素生物合成途径被认为是广谱抗生素治疗靶点的丰富资源。本文综述了核黄素生物合成的酶途径、调控因子及相关药物发现。还描述了核黄素代谢的新型核糖开关调控机制。本文列出了化学调节剂对核黄素生物合成和调控网络的综合分析，这表明核黄素生物合成和调控机制作为新型抗生素药物发现的潜在治疗靶点具有广阔的前景。
