前所未有的立方体型刚性稳定磷脂脂质体的形成。

Unprecedented formation of sterically stabilized phospholipid liposomes of cuboidal morphology.

机构信息

Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St., Bl. 103-A, 1113 Sofia, Bulgaria.

Center of Polymer and Carbon Materials, Polish Academy of Sciences, ul. M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland.

出版信息

Nanoscale. 2021 Sep 23;13(36):15210-15214. doi: 10.1039/d1nr02856a.

DOI:10.1039/d1nr02856a

PMID:34490863

Abstract

Sterically stabilized phospholipid liposomes of unprecedented cuboid morphology are formed upon introduction in the bilayer membrane of original polymers, based on polyglycidol bearing a lipid-mimetic residue. Strong hydrogen bonding in the polyglycidol sublayers creates attractive forces, which, facilitated by fluidization of the membrane, bring about the flattening of the bilayers and the formation of cuboid vesicles.

摘要

在将基于带有脂质模拟物残基的聚缩水甘油的原始聚合物引入双层膜中时，会形成具有前所未有的立方形形态的位阻稳定磷脂脂质体。聚缩水甘油亚层中的强氢键会产生吸引力，在膜的流态化的促进下，导致双层的扁平化和立方形囊泡的形成。