双核锌催化的 3-氨基酚与α,α-二氰代烯烃的不对称 Friedel-Crafts 烷基化/环化反应。
Dinuclear zinc-catalyzed asymmetric Friedel-Crafts alkylation/cyclization of 3-aminophenols with α,α-dicyanoolefins.
机构信息
Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
出版信息
Chem Commun (Camb). 2021 Sep 28;57(77):9854-9857. doi: 10.1039/d1cc04177k.
PMID:34490871
Abstract
An enantioselective Friedel-Crafts alkylation/cyclization tandem reaction of 3-aminophenols with α,α-dicyanoolefins has been performed successfully using a chiral dinuclear zinc catalyst, leading to a range of chiral 2-amino-4-chromenes (up to 98% yield and >99% ee). To the best of our knowledge, this is the first asymmetric example of the dinuclear zinc-catalysed functionalization of aromatic C(sp)-H bonds.
摘要
3-氨基酚与α,α-二氰代烯烃的对映选择性Friedel-Crafts 烷基化/环化串联反应已成功使用手性双核锌催化剂进行，得到一系列手性 2-氨基-4-色烯（高达 98%的产率和>99%的对映选择性）。据我们所知，这是双核锌催化芳基 C(sp)-H 键功能化的首例不对称实例。
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