手性噁唑硼烷离子催化剂促进的呋喃与 - 醌甲醚的对映选择性 Friedel-Crafts 烷基化反应。
Enantioselective Friedel-Crafts Alkylation of Furans with -Quinone Methide Using a Chiral Oxazaborolidinium Ion Catalyst.
机构信息
Department of Chemistry, Sungkyunkwan University, 300 Cheoncheon, Jangan, Suwon 16419, Korea.
出版信息
Org Lett. 2022 Mar 4;24(8):1732-1736. doi: 10.1021/acs.orglett.2c00404. Epub 2022 Feb 23.
PMID:35195002
Abstract
A chiral Lewis acid-catalyzed enantioselective Friedel-Crafts furan alkylation with in situ-generated -quinone methides has been developed. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in high yield (up to 99%) with excellent enantioselectivity (up to >99% ).
摘要
手性路易斯酸催化的对映选择性 Friedel-Crafts 呋喃烷基化反应与原位生成的 -醌甲醚的反应已经被开发出来。在手性噁唑硼烷离子催化剂的存在下，该反应以高产率（高达 99%）和优异的对映选择性（高达 >99%）进行。
Zotero 插件