Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China.
Key Laboratory of the Science and Technology Department of Jilin Province, Yanji, China.
Carcinogenesis. 2022 Feb 11;43(1):40-51. doi: 10.1093/carcin/bgab081.
Mortalin is involved in the malignant phenotype of many cancers. However, the specific molecular mechanisms involving Mortalin in lung adenocarcinoma remain unclear. In this study, we showed that both Mortalin mRNA and protein are overexpressed in lung adenocarcinoma. In addition, Mortalin overexpression was positively correlated with poor overall survival. In vitro experiments showed that Mortalin silencing inhibited the proliferation, colony formation and migration abilities of A549 and H1299 cells. Mortalin promotes EMT progression, angiogenesis and tumor progression by activating the Wnt/β-catenin signaling pathway. In vivo experiments further confirmed that Mortalin promoted malignant progression of lung adenocarcinoma. Taken together, our data suggest that Mortalin represents an attractive prognostic marker and therapeutic target in lung adenocarcinoma patients.
线粒体蛋白在许多癌症的恶性表型中都有涉及。然而，线粒体蛋白在肺腺癌中涉及的具体分子机制尚不清楚。在这项研究中，我们表明线粒体蛋白 mRNA 和蛋白在肺腺癌中均过度表达。此外，线粒体蛋白过表达与整体生存不良呈正相关。体外实验表明，线粒体蛋白沉默抑制了 A549 和 H1299 细胞的增殖、集落形成和迁移能力。线粒体蛋白通过激活 Wnt/β-catenin 信号通路促进 EMT 进展、血管生成和肿瘤进展。体内实验进一步证实，线粒体蛋白促进了肺腺癌的恶性进展。总之，我们的数据表明，线粒体蛋白代表了肺腺癌患者有吸引力的预后标志物和治疗靶点。
