Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Key Laboratory of the Science and Technology, Department of Jilin Province, Yanji, China.
Department of Health Examination Centre, Yanbian University Hospital, Yanji 133002, China.
Exp Mol Pathol. 2021 Feb;118:104593. doi: 10.1016/j.yexmp.2020.104593. Epub 2020 Dec 9.
Mortalin is a member of the heat shock protein 70 (HSP70) family that promotes the development of many cancers. It is reportedly a tumor promoter, but the mechanism of Mortalin in breast cancer is unclear. We designed a series of experiments to explore the correlation between Mortalin and the malignancy of breast cancer, and to assess the potential of Mortalin as a novel therapeutic target in breast cancer. The expression level of Mortalin in breast cancer tissues was detected. Then, we did a series of functional experiment. The findings indicated that Mortalin facilitates the proliferation, metastasis, and endothelial-to-mesenchymal transition (EMT) process of breast cancer. In our research, Mortalin is regulated EMT process and malignant progression of breast cancer through Wnt/β-Catenin signaling pathway. The findings imply that Mortalin significantly promotes the progression of breast cancer malignancy and reduces patient survival, suggesting that Mortalin as a biomarker and prognostic factor in breast cancer.
线粒体蛋白是热休克蛋白 70（HSP70）家族的一员，可促进多种癌症的发展。有报道称其是一种肿瘤促进剂，但线粒体蛋白在乳腺癌中的作用机制尚不清楚。我们设计了一系列实验来探讨线粒体蛋白与乳腺癌恶性程度的相关性，并评估其作为乳腺癌新型治疗靶点的潜力。检测了乳腺癌组织中线粒体蛋白的表达水平。然后，我们进行了一系列功能实验。结果表明，线粒体蛋白促进了乳腺癌的增殖、转移和内皮间质转化（EMT）过程。在我们的研究中，线粒体蛋白通过 Wnt/β-连环蛋白信号通路调节 EMT 过程和乳腺癌的恶性进展。这些发现表明，线粒体蛋白显著促进了乳腺癌恶性程度的进展，降低了患者的生存率，提示线粒体蛋白可作为乳腺癌的生物标志物和预后因素。
