College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan Province, China.
Aging (Albany NY). 2021 Sep 6;13(17):21451-21469. doi: 10.18632/aging.203484.
To summarize and assess the credibility and strength of non-genetic factors and genetic variation on gastric cancer risk, we performed a field synopsis and meta-analysis to identify the risk of gastric cancer in Chinese population. Cumulative evidence was graded according to the Venice criteria, and attributable risk percentage () and population attributable risk percentage () were used to evaluate the epidemiological effect. A total of 956 studies included non-genetic (404 studies) and genetic factors (552 studies) were quantified, and data on 1161 single nucleotide polymorphisms (SNPs) were available. We identified 14 non-genetic factors were significantly associated with gastric cancer risk. For the analysis of time trends, infection rate in gastric cancer and population showed a downward trend. Meanwhile 22 variants were identified significantly associated with gastric cancer: 3 ( rs2274223, rs2976392, rs4072037) were high and 19 SNPs were intermediate level of summary evidence, respectively. For non-genetic factors, the top three for were 54.75% (pickled food), 65.87% (stomach disease), and 49.75% (smoked and frying). For were 34.22% (pickled food), 34.24% (edible hot food) and 23.66%( infection). On the basis of and associated with SNPs of gastric cancer, the top three for were 53.91% (, rs1799929),53.05% ( phenotype), and 42.85% (, rs1800896). For (Chinese Han in Beijing) were 36.96% (, rs731236), 25.58% (, rs3773651) and 20.56% (, rs4072037). Our study identified non-genetic risk factors and high-quality biomarkers of gastric cancer susceptibility and their contribution to gastric cancer.
为了总结和评估非遗传因素和遗传变异对胃癌风险的可信度和强度，我们进行了现场综述和荟萃分析，以确定中国人群胃癌的风险。根据威尼斯标准对累积证据进行分级，并使用归因风险百分比（）和人群归因风险百分比（）来评估流行病学效应。共纳入了 956 项非遗传因素（404 项）和遗传因素（552 项）的研究，并获得了 1161 个单核苷酸多态性（SNP）的数据。我们确定了 14 个非遗传因素与胃癌风险显著相关。对于时间趋势分析，胃癌和人群的 感染率呈下降趋势。同时，确定了 22 个与胃癌显著相关的变异：3 个（rs2274223、rs2976392、rs4072037）为高水平，19 个 SNP 为中高水平的汇总证据。对于非遗传因素，的前三位是 54.75%（腌制食品）、65.87%（胃病）和 49.75%（熏制和油炸食品）。对于，前三位是 34.22%（腌制食品）、34.24%（可食用热食）和 23.66%（感染）。基于与胃癌 SNP 相关的和，的前三位是 53.91%（，rs1799929）、53.05%（表型）和 42.85%（，rs1800896）。对于（北京汉族人），前三位是 36.96%（，rs731236）、25.58%（，rs3773651）和 20.56%（，rs4072037）。我们的研究确定了非遗传风险因素和胃癌易感性的高质量生物标志物及其对胃癌的贡献。
