Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department of Molecular Genetics, Otto von Guericke University, Magdeburg, Germany.
Anticancer Res. 2014 Dec;34(12):7167-75.
BACKGROUND/AIM: Genome-wide association studies revealed a link between gastric cancer (GC) and single nucleotide polymorphisms (SNPs) of prostate stem cell antigen (PSCA), phospholipase C epsilon-1 (PLCE1) and mucin-1 (MUC1) genes. Herein, we aimed to evaluate associations between PSCA (C>T, rs2294008; G>A, rs2976392), MUC1 (C>T, rs4072037) and PLCE1 (A>G, rs2274223) SNPs and GC or high-risk gastritis (HRAG).
Using TaqMan system, SNPs were genotyped in 252 patients with GC, 136 patients with HRAG and 246 controls.
PSCA rs2294008 allele T was associated with risk of GC (odds ratio (OR)=1.88, p<0.001) and HRAG (OR=1.49, p=0.009). Allele A of PSCA rs2976392 was associated with development of GC (OR=1.88, p<0.001) and HRAG (OR=1.56, p<0.01). MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223.
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
背景/目的：全基因组关联研究揭示了前列腺干细胞抗原（PSCA）、磷脂酶 C ε-1（PLCE1）和黏蛋白-1（MUC1）基因的单核苷酸多态性（SNP）与胃癌（GC）之间存在关联。在此，我们旨在评估 PSCA（C>T，rs2294008；G>A，rs2976392）、MUC1（C>T，rs4072037）和 PLCE1（A>G，rs2274223）SNP 与 GC 或高危胃炎（HRAG）之间的关联。
使用 TaqMan 系统，对 252 例 GC 患者、136 例 HRAG 患者和 246 例对照进行了 SNP 基因分型。
PSCA rs2294008 等位基因 T 与 GC（比值比（OR）=1.88，p<0.001）和 HRAG（OR=1.49，p=0.009）的发病风险相关。PSCA rs2976392 的等位基因 A 与 GC（OR=1.88，p<0.001）和 HRAG（OR=1.56，p<0.01）的发病相关。MUC1 rs4072037 等位基因 G 对 GC 的发生具有保护作用（OR=0.64，p=0.0005），而 PLCE1 rs2274223 则没有差异。
PSCA（rs2976392、rs2294008）和 MUC1（rs4072037）基因的多态性与 GC 和 HRAG 相关。
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