在银屑病关节炎中 MCAM（CD146）T 细胞亚群的表型和病理意义。

Phenotype and pathological significance of MCAM (CD146) T cell subset in psoriatic arthritis.

机构信息

University of California Davis School of Medicine, Sacramento, USA.

Sacramento VA Medical Center, 10535 Hospital Way, Mather, CA, 95655, USA.

出版信息

Mol Biol Rep. 2021 Oct;48(10):6787-6796. doi: 10.1007/s11033-021-06678-2. Epub 2021 Sep 7.

BACKGROUND

CD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146IL-17 memory T cells in PsA synovium and studied the association of CD146 expression and CD4IL-17 activated memory (CD11aCD45RO) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients.

METHODS

Hi-D FACS studies were done to identify IL-17 in CD4CD146CD45RO and CD8CD146CD45RO T cells.

RESULTS

We observed that effector CD146(MCAM) T cells are enriched at the synovial inflammation site in PsA.

CONCLUSION

As CD146 T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM pathologic cells are critical for the disease process of PsA.

背景

CD146（MCAM-黑色素瘤细胞黏附分子）是层粘连蛋白 411 的细胞表面黏附分子。表达 MCAM 的 T 细胞主要负责产生 IL-17。分泌 IL-17 的辅助性 T 细胞（Th17 细胞）对于银屑病关节炎（PsA）的发病机制至关重要。在这里，我们假设 CD146IL-17 记忆 T 细胞在 PsA 滑膜中富集，并研究了 CD146 表达与滑膜液和 PSA、类风湿关节炎（RA，阳性对照）和骨关节炎（OA）患者血液中 CD4IL-17 激活的记忆（CD11aCD45RO）T 细胞之间的关联。