Zhou Shaoqiang, Qian Kebao, Yu Shuhui, Zhao Yutao, Shen Qin, Li Ya
Department of Breast Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Department of Thoracic Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Cancer Biother Radiopharm. 2024 Oct;39(8):562-572. doi: 10.1089/cbr.2021.0154. Epub 2021 Sep 2.
Lung adenocarcinoma (ADC) is a common subtype of non-small cell lung cancer. MicroRNAs have been reported to be effective biomarkers for diagnosis and an important target for therapy. MiR-4429 is a newly identified miRNA, which can take part in tumor progression as a tumor inhibitor. Moreover, it is an exosomal miRNA that can be taken by lung ADC cell line A549. Nevertheless, its role in lung ADC has been poorly studied. This research discovered that miR-4429 was low expressed in lung ADC cells. MiR-4429 mimics could alleviate the capacities of cell proliferation and metastasis. The mimics are able to reverse epithelial-mesenchymal transition at the same time. Furthermore, it was verified that miR-4429 could bind to and negatively regulate expression. Interestingly, SKL2001 can reverse the role of miR-4429 on tumor. Consequently, miR-4429 can inactivate signaling pathway by targeting and prevent oncogene expression in lung ADC cells.
肺腺癌（ADC）是非小细胞肺癌的常见亚型。据报道，微小RNA是有效的诊断生物标志物和重要的治疗靶点。MiR-4429是一种新发现的微小RNA，可作为肿瘤抑制因子参与肿瘤进展。此外，它是一种外泌体微小RNA，可被肺腺癌细胞系A549摄取。然而，其在肺腺癌中的作用研究较少。本研究发现miR-4429在肺腺癌细胞中低表达。MiR-4429模拟物可以减轻细胞增殖和转移能力。模拟物能够同时逆转上皮-间质转化。此外，证实miR-4429可以结合并负向调节表达。有趣的是，SKL2001可以逆转miR-4429对肿瘤的作用。因此，miR-4429可以通过靶向使信号通路失活，并阻止肺腺癌细胞中癌基因的表达。
