Diamant S C, Scott R B
Department of Pediatrics, University of Calgary, Alta., Canada.
Can J Physiol Pharmacol. 1987 Nov;65(11):2269-73. doi: 10.1139/y87-359.
To determine if migrating action potential complexes (MAPCs) are a feature of normal motility, Hooded-Lister rats (100-150 g) were surgically prepared with three pairs of bipolar jejunal electrodes spaced 2.5 cm apart and with a jejunostomy tube for motility recording. Animals were studied conscious and unrestrained on postoperative day 14 after an 18-h fast. Intestinal myoelectric and motor activity was recorded for a 1-h interval in 24 animals that continued to fast and in 12 animals that were allowed to feed for 10 min. Fasting rats had a jejunal slow wave frequency of 32 +/- 2 contractions/min which did not differ significantly after feeding. Migrating myoelectric complexes (MMC) were clearly identified in all fasting animals and had a cycle period of 10.0 +/- 3.6 min. MAPCs were seen during phase II in 83% of MMCs and had an average distribution of 4.2 +/- 3.9/MMC. Feeding abolished the MMC and initiated a continuous irregular pattern of electrical spiking and associated contractile activity. Migrating action potential complexes were seen after feeding with a frequency of 1.8 +/- 0.4/min. It is concluded that MAPCs are a common feature of normal interdigestive phase II and also of postprandial jejunal motility in the rat. This supports the hypothesis that the MAPC is a basic propulsive motor pattern intrinsic to normal intestinal function.
为了确定移行性动作电位复合体（MAPCs）是否为正常胃肠蠕动的一个特征，对体重100 - 150克的帽状利斯特大鼠进行手术，植入三对相距2.5厘米的双极空肠电极，并植入一个空肠造口管用于记录胃肠蠕动。在术后第14天，对动物在禁食18小时后进行清醒且不受限制的研究。对24只继续禁食的动物和12只允许进食10分钟的动物的肠肌电和运动活动进行1小时的记录。禁食大鼠的空肠慢波频率为32±2次收缩/分钟，进食后无显著差异。在所有禁食动物中均清晰识别出移行性肌电复合体（MMC），其周期为10.0±3.6分钟。在83%的MMC的II期可见MAPCs，平均分布为4.2±3.9个/MCC。进食使MMC消失，并引发连续的不规则电尖峰模式及相关的收缩活动。进食后可见移行性动作电位复合体，频率为1.8±0.4次/分钟。得出的结论是，MAPCs是大鼠正常消化间期II期以及餐后空肠蠕动的共同特征。这支持了以下假设，即MAPC是正常肠道功能固有的一种基本推进性运动模式。
