1 Veterinary Cabinet Uz Bence SRL, Szentegyháza (Vlahita), Romania.
2 MTA-SZIE Large Animal Clinical Research Group, Üllő, Hungary.
Acta Vet Hung. 2021 Sep 7;69(3):256-265. doi: 10.1556/004.2021.00031.
A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.
特兰西瓦尼亚哈采格县的一个特定区域内流行一种严重的复发性运动性横纹肌溶解症。在海拔最高的两个定居点（海拔 800 米以上），马的横纹肌溶解症患病率在 17%至 23%之间，而在山谷中的邻近村庄，其患病率则低于 2%。我们的研究目的是阐明硒和维生素 E 在该地区高发横纹肌溶解症中的作用。从每个地区采集土壤和干草样本，以评估矿物质含量。从非发病区和发病区各选取 10 匹马和 20 匹马进行血清硒、维生素 E、谷胱甘肽过氧化物酶（GSH-Px）、肌肉酶、乳酸和电解质检测。发病区采集的干草样本硒含量较低。发病区的马匹血清硒（P = 0.006）和 GSH-Px 水平明显低于非发病区的动物。可以证明红细胞 GSH-Px 与血清硒浓度之间存在良好的相关性（r = 0.777，P < 0.001）。血清维生素 E 水平低与马的来源无关。基于我们的结果，硒缺乏可能在特兰西瓦尼亚地方性马复发性横纹肌溶解症综合征中起作用。
