日本母体暴露于细颗粒物及其成分与出生体重和胎盘重量的特定孕期关联。
Trimester-Specific Association of Maternal Exposure to Fine Particulate Matter and its Components With Birth and Placental Weight in Japan.
机构信息
Department of Environmental and Occupational Health, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan (Dr Takeda, Dr Michikawa, and Dr Nishiwaki); Department of Environmental and Occupational Health, School of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan (Dr Michikawa and Dr Nishiwaki); Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan (Dr Morokuma); Health and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan (Dr Yamazaki and Dr Nitta); Department of Obstetrics and Gynaecology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan (Dr Nakahara and Dr Kato); Regional Environment Conservation Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan (Dr Yoshino, Dr Sugata, and Dr Takami); Tokyo Metropolitan Research Institute for Environmental Protection, 1-7-5 Shinsuna, Koto-ku, Tokyo 136-0075, Japan (Dr Saito and Dr Hoshi).
出版信息
J Occup Environ Med. 2021 Sep 1;63(9):771-778. doi: 10.1097/JOM.0000000000002254.
OBJECTIVE
We investigated which trimester of exposure to PM2.5 and its components was associated with birth and placental weight, and the fetoplacental weight ratio.
METHODS
The study included 63,990 women who delivered singleton term births within 23 Tokyo wards between 2013 and 2015. Each day, we collected fine particles on a filter, and analyzed their chemical constituents, including carbons and ions. Trimester-specific exposure to each pollutant was estimated based on the average daily concentrations.
RESULTS
Over the third trimester, sulfate exposure tended to be inversely associated with birth weight, and decreased placental weight (difference for highest vs lowest quintile groups = -6.7 g, 95% confidence interval = -12.5 to -0.9). For fetoplacental weight ratio, there was no relationship.
CONCLUSIONS
Sulfate exposure over the third trimester may reduce birth weight, particularly placental weight.
目的
本研究旨在探讨 PM2.5 及其成分在哪个孕期阶段与出生体重和胎盘重量以及胎-盘重量比相关。
方法
该研究纳入了 2013 年至 2015 年间在东京 23 个区分娩的 63990 名单胎足月分娩的女性。我们每天在滤纸上收集细颗粒物，并分析其化学成分，包括碳和离子。根据日均浓度来估计每个污染物在孕期各阶段的暴露情况。
结果
在孕晚期，硫酸盐暴露与出生体重呈负相关趋势，且降低了胎盘重量（最高五分位组与最低五分位组差值为-6.7g，95%置信区间为-12.5 至-0.9）。对于胎-盘重量比，没有相关性。
结论
孕晚期硫酸盐暴露可能会降低出生体重，尤其是胎盘重量。
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