Diagnostic Imaging, Department of Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Clinical Pathology Platform, Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria.
J Feline Med Surg. 2022 Jun;24(6):565-579. doi: 10.1177/1098612X211038535. Epub 2021 Sep 8.
The aim of this study was to determine the prevalence of post-contrast acute kidney injury or comparable side effects on kidney function in cats receiving the non-ionic, iodinated agent ioversol and/or paramagnetic agent gadoteric acid.
Fifty-two animals were divided into four groups on the basis of contrast medium administration for imaging: ioversol (n = 27), gadoteric acid (n = 12), dual contrast media (n = 4) or control, which received an infusion of isotone intravenous fluids only during anaesthesia (n = 9). Blood and urine samples were obtained three times after contrast administration and compared with values obtained prior to administration of the contrast medium. Creatinine (<1.60 mg/dl), symmetric dimethylarginine (SDMA; ⩽14 μg/dl), urine protein:creatinine ratio (UPC; <0.2) and critical differences for creatinine (<0.3 mg/dl) and SDMA (<5.98 μg/dl) were measured.
No significant short-term effects on mean creatinine, SDMA and UPC measurements were seen. Borderline proteinuria (UPC, 0.2-0.4) was detected in 11.4% of cases after contrast media administration. A UPC of more than 0.2 in five cases indicated that contrast media may affect kidney function, leading to (transient) proteinuria.
This study found no side effect on renal function following the administration of ioversol or gadoteric acid, provided patients were adequately hydrated. However, the clinical relevance of proteinuria in some cats needs to be evaluated in future studies.
本研究旨在确定接受非离子型碘造影剂碘海醇和/或顺磁性造影剂钆特酸的猫在造影后是否会出现急性肾损伤或类似的肾功能副作用。
52 只动物根据造影剂的使用情况分为四组进行影像学检查：碘海醇组（n=27）、钆特酸组（n=12）、双重造影剂组（n=4）或对照组（n=9），仅在麻醉期间接受等渗静脉输液。在造影后三次采集血样和尿样，并与造影前的数值进行比较。检测肌酐（<1.60mg/dl）、对称二甲基精氨酸（SDMA；⩽14μg/dl）、尿蛋白/肌酐比值（UPC；<0.2）和肌酐（<0.3mg/dl）及 SDMA（<5.98μg/dl）的临界差值。
未发现平均肌酐、SDMA 和 UPC 测量值有明显的短期影响。在造影后，有 11.4%的病例检测到边界性蛋白尿（UPC，0.2-0.4）。在 5 例病例中，UPC 超过 0.2 表明造影剂可能影响肾功能，导致（短暂）蛋白尿。
本研究发现，在充分水化的情况下，使用碘海醇或钆特酸对肾功能无副作用。然而，一些猫出现蛋白尿的临床意义需要在未来的研究中进一步评估。
