血清素转运体和受体基因多态性对抑郁症的影响。
Effects of Serotonin Transporter and Receptor Polymorphisms on Depression.
作者信息
López-Echeverri Yéssica P, Cardona-Londoño Kelly J, Garcia-Aguirre Jhonny F, Orrego-Cardozo Mary
机构信息
Laboratorio de Neurofisiología, Departamento de Ciencias Básicas, Universidad Autónoma de Manizales, Manizales, Colombia.
Laboratorio de Neurofisiología, Departamento de Ciencias Básicas, Universidad Autónoma de Manizales, Manizales, Colombia.
出版信息
Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 4. doi: 10.1016/j.rcp.2021.07.006.
INTRODUCTION
Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics.
OBJECTIVE
A review of research reports that have studied the effects of variations in the serotonin transporter and receptor genes on different clinical features of depression.
METHODS
A search of the Scopus, Web of Science and PubMed databases was conducted using the keywords ("depression" AND "polymorphism").
CONCLUSIONS
According to the review of 54 articles, the short allele of the 5-HTTLPR polymorphism was found to be the most reported risk factor related to the development of depression and its severity. Variations in the genes studied (SLC6A4, HTR1A, HTR2A) can generate morphological alterations of brain structures.
引言
血清素与情绪状态的调节和认知任务的执行密切相关，以至于血清素转运体基因（5-HTT，SLC6A4）和血清素受体基因（HTR1A、HTR1B、HTR2A）在研究这些基因及其多态性变异对抑郁特征的影响时，成为了理想的候选对象。
目的
综述研究血清素转运体和受体基因变异对抑郁症不同临床特征影响的研究报告。
方法
使用关键词（“抑郁症”和“多态性”）在Scopus、科学网和PubMed数据库中进行检索。
结论
根据对54篇文章的综述，发现5-HTTLPR多态性的短等位基因是与抑郁症发生及其严重程度相关的最常报道的危险因素。所研究的基因（SLC6A4、HTR1A、HTR2A）的变异可导致脑结构的形态改变。
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