Department of Clinical Oncology, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 1/F Professorial Block, 102 Pokfulam Road, Hong Kong.
Division of Gynaecology Oncology, Department of Obstetrics and Gynaecology, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 6/F Professorial Block, 102 Pokfulam Road, Hong Kong.
Best Pract Res Clin Obstet Gynaecol. 2022 Jan;78:74-85. doi: 10.1016/j.bpobgyn.2021.06.001. Epub 2021 Aug 4.
Non-epithelial cancers arising from the ovary are uncommon malignancies. Germ cell tumors of the ovary arise from primordial germ cells, and sex cord-stromal tumors of the ovary represent a cluster of tumors arising from the sex cord and stromal compartment. Most patients diagnosed with germ cell tumors are young adults and adolescent females. In contrast, ovarian sex cord-stromal tumors more commonly occur in a mature age group. Advances in the adjuvant management of non-epithelial ovarian cancer following optimal surgical and pathological staging have improved patient survival outcomes. In addition, active surveillance is preferentially assigned to patients diagnosed with stage I germ cell tumor, stage 1A grade 1 immature teratoma, stage 1A yolk sac tumor, and stage 1AI sex cord-stromal tumors. This article discusses the importance of selecting the adjuvant treatment approach most suitable to the patients' surgical and pathological stages, thereby safeguarding patient outcomes.
非上皮性卵巢癌是罕见的恶性肿瘤。卵巢生殖细胞肿瘤来源于原始生殖细胞，而卵巢性索-间质肿瘤则是一组来源于性索和间质成分的肿瘤。大多数诊断为生殖细胞肿瘤的患者为年轻成年女性和青少年女性。相比之下，卵巢性索-间质肿瘤更常见于成熟年龄组。在进行最佳手术和病理分期后，非上皮性卵巢癌的辅助治疗进展改善了患者的生存结局。此外，对于诊断为 I 期生殖细胞瘤、IA 级 1 级未成熟畸胎瘤、IA 期卵黄囊瘤和 IAI 期性索-间质肿瘤的患者，通常采用主动监测。本文讨论了根据患者的手术和病理分期选择最适合的辅助治疗方法的重要性，从而保障患者的预后。
