伴淋巴样间质的微结节性胸腺瘤与微结节性胸腺癌的临床病理及免疫组化对比研究
Comparative clinicopathological and immunohistochemical study of micronodular thymoma and micronodular thymic carcinoma with lymphoid stroma.
作者信息
Liu Ping Ping, Su Yun Chao, Niu Yun, Shi Yan Fen, Luo Jie, Zhong Ding Rong
机构信息
Department of Pathology, China Japan Friendship Hospital, Beijing, China.
Department of Pathology, China Japan Friendship Hospital, Beijing, China
出版信息
J Clin Pathol. 2021 Sep 7;75(10):702-5. doi: 10.1136/jclinpath-2021-207819.
AIM
To elucidate the clinicopathological and immunohistochemical characteristics of micronodular thymomas (MNTs) and micronodular thymic carcinomas (MNCs) with lymphoid stroma.
METHODS
We examined four cases of MNTs and three cases of MNCs pathologically and immunohistochemically.
RESULTS
There were prominent cystic changes infive of the seven cases. The neoplasms contained epithelial tumour cells arranged in a micronodular growth pattern lined by cystic walls and separated by abundant lymphoid stroma. Only the tumour cell component of MNCs showed signs of malignancy characterised by cytological atypia and increased mitotic activity. Neoplastic MNC epithelial cells showed strong positivity for CD5 and CD117. However, no immature lymphocytes (TdT-positive and CD99-positive) were present in and around the tumour nodules. None of the patients died or suffered from disease due to MNTs or MNCs.
CONCLUSION
MNTs and MNCs are rare and less aggressive forms of thymic tumours and can be differentially diagnosed by immunohistochemistry.
目的
阐明具有淋巴样间质的微结节型胸腺瘤（MNTs）和微结节型胸腺癌（MNCs）的临床病理及免疫组化特征。
方法
我们对4例MNTs和3例MNCs进行了病理及免疫组化检查。
结果
7例中有5例有显著的囊性改变。肿瘤包含上皮性肿瘤细胞，呈微结节状生长模式，被囊壁包绕，且被丰富的淋巴样间质分隔。仅MNCs的肿瘤细胞成分显示出恶性特征，表现为细胞学异型性和有丝分裂活性增加。肿瘤性MNC上皮细胞对CD5和CD117呈强阳性。然而，在肿瘤结节内及其周围未发现未成熟淋巴细胞（TdT阳性和CD99阳性）。没有患者因MNTs或MNCs死亡或患病。
结论
MNTs和MNCs是罕见且侵袭性较小的胸腺肿瘤形式，可通过免疫组化进行鉴别诊断。
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