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MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness.

作者信息

Liu Yahui, Du Juan, Liu Xinnan, Wang Lingbiao, Han Yichao, Huang Chunrong, Liang Rui, Zheng Fang, Shi Guochao, Li Bin

机构信息

Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Signal Transduct Target Ther. 2021 Sep 8;6(1):321. doi: 10.1038/s41392-021-00667-4.

DOI:10.1038/s41392-021-00667-4
PMID:34493712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8423820/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeaf/8423820/4973d2e5c007/41392_2021_667_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeaf/8423820/4973d2e5c007/41392_2021_667_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeaf/8423820/4973d2e5c007/41392_2021_667_Fig1_HTML.jpg

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Lancet. 2019 Aug 3;394(10196):407-418. doi: 10.1016/S0140-6736(19)31147-X. Epub 2019 Jun 20.
2
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Pulm Pharmacol Ther. 2017 Jun;44:88-95. doi: 10.1016/j.pupt.2017.03.006. Epub 2017 Mar 16.
3
Epidemiology of asthma.
Front Immunol. 2025 Jan 24;16:1533335. doi: 10.3389/fimmu.2025.1533335. eCollection 2025.
4
KAT8 beyond Acetylation: A Survey of Its Epigenetic Regulation, Genetic Variability, and Implications for Human Health.KAT8 超越乙酰化：对其表观遗传调控、遗传变异性及其对人类健康影响的综述。
Genes (Basel). 2024 May 17;15(5):639. doi: 10.3390/genes15050639.
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Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction.剖析核白细胞介素-33（nIL-33）的复杂性：转录和信号转导的关键调节因子。
J Cell Commun Signal. 2023 Dec;17(4):1131-1143. doi: 10.1007/s12079-023-00788-1. Epub 2023 Oct 25.
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Gene-Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors.基因-吸烟相互作用分析鉴定新的哮喘相关遗传因素。
Int J Mol Sci. 2023 Jul 31;24(15):12266. doi: 10.3390/ijms241512266.
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