阿吡坦在大鼠和人体中的初步代谢研究。
A preliminary metabolic study of alpidem in rat and man.
作者信息
Padovani P, Guinebault P, Vajta S, Durand A, Allen J, Thenot J P, Morselli P L
机构信息
Laboratoire d'Etudes et de Recherches Synthélabo Paris, France.
出版信息
Eur J Drug Metab Pharmacokinet. 1987 Oct-Dec;12(4):295-8. doi: 10.1007/BF03189916.
PMID:3449388
Abstract
The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or aliphatic oxidation of the substituted amide side chains.
摘要
对新型抗焦虑药阿吡坦（属于咪唑并吡啶化学系列）在大鼠和人体中的代谢情况进行了研究。在这两个物种中，该化合物主要通过三种生物转化途径进行广泛代谢：咪唑并吡啶环的芳香族氧化；N-脱烷基化；和/或取代酰胺侧链的脂肪族氧化。
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