饮食中的维生素 A 与黑人女性的乳腺癌风险：非裔美国乳腺癌流行病学和风险（AMBER）联盟。
Dietary Vitamin A and Breast Cancer Risk in Black Women: The African American Breast Cancer Epidemiology and Risk (AMBER) Consortium.
机构信息
Department of Epidemiology, University of Florida, Gainesville FL, USA.
Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
出版信息
J Nutr. 2021 Dec 3;151(12):3725-3737. doi: 10.1093/jn/nxab278.
BACKGROUND
Studies in women of European descent showed an inverse association of dietary vitamin A (retinol and carotenoids) intake with breast cancer risks, mainly in premenopausal women.
OBJECTIVES
We examined whether higher compared with lower levels of dietary vitamin A are associated with reduced breast cancer risks among Black women by estrogen receptor (ER) and menopausal statuses.
METHODS
In this pooled analysis, data were from 3564 breast cancer cases and 11,843 controls (mean ages = 56.4 and 56.3 years, respectively) in the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. Dietary intake was assessed by FFQs. Multivariable logistic regressions were performed to estimate ORs and 95% CIs for study-specific quintiles of total vitamin A equivalents and individual carotenoids, and a pooled OR was estimated by a random-effect model.
RESULTS
We observed an inverse association of total vitamin A equivalents with ER-positive breast cancer (quintiles 5 compared with 1: pooled OR: 0.82; 95% CI: 0.67-1.00; P-trend = 0.045). The association was seen among premenopausal women (pooled OR: 0.60; 95% CI: 0.43-0.83; P-trend = 0.004), but not among postmenopausal women (pooled OR: 0.99; 95% CI: 0.77-1.28; P-trend = 0.78). Additionally, there were inverse associations of dietary β-carotene (quintiles 5 compared with 1: pooled OR: 0.70; 95% CI: 0.51-0.95; P-trend = 0.08) and lutein (pooled OR: 0.63; 95% CI: 0.45-0.87; P-trend = 0.020) with ER-positive breast cancer among premenopausal women. There was no evidence for an association of total vitamin A equivalents or individual carotenoids with ER-negative breast cancer, regardless of menopausal status.
CONCLUSIONS
Our findings on dietary vitamin A and breast cancer risks in Black women are consistent with observations in women of European descent and advance the literature showing an inverse association for ER-positive disease.
背景
在欧洲裔女性中进行的研究表明，膳食维生素 A（视黄醇和类胡萝卜素）摄入与乳腺癌风险呈负相关，主要发生在绝经前女性中。
目的
我们通过雌激素受体（ER）和绝经状态检查了较高水平的膳食维生素 A 是否与黑人女性患乳腺癌风险降低有关。
方法
在这项汇总分析中，数据来自非洲裔美国乳腺癌流行病学和风险（AMBER）联盟的 3564 名乳腺癌病例和 11843 名对照者（平均年龄分别为 56.4 岁和 56.3 岁）。膳食摄入量通过 FFQ 进行评估。使用多变量逻辑回归来估计研究特定的总维生素 A 当量和个体类胡萝卜素五分位数的 OR 和 95%CI，并通过随机效应模型估计汇总 OR。
结果
我们发现总维生素 A 当量与 ER 阳性乳腺癌呈负相关（五分位 5 与 1 相比：汇总 OR：0.82；95%CI：0.67-1.00；P 趋势=0.045）。这种关联存在于绝经前妇女中（汇总 OR：0.60；95%CI：0.43-0.83；P 趋势=0.004），但不存在于绝经后妇女中（汇总 OR：0.99；95%CI：0.77-1.28；P 趋势=0.78）。此外，β-胡萝卜素（五分位 5 与 1 相比：汇总 OR：0.70；95%CI：0.51-0.95；P 趋势=0.08）和叶黄素（汇总 OR：0.63；95%CI：0.45-0.87；P 趋势=0.020）与 ER 阳性乳腺癌呈负相关，且仅存在于绝经前妇女中。无论绝经状态如何，总维生素 A 当量或个体类胡萝卜素与 ER 阴性乳腺癌均无关联。
结论
我们在黑人女性中发现的膳食维生素 A 与乳腺癌风险的关系与欧洲裔女性的观察结果一致，并进一步证明了与 ER 阳性疾病呈负相关的关系。
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