Hangzhou Third People's Hospital, Department of Anesthesiology and Pain Medicine - Hangzhou, China.
Rev Assoc Med Bras (1992). 2021 Apr;67(4):585-589. doi: 10.1590/1806-9282.20201124.
The aim of this study was to evaluate the efficacy of high-voltage pulsed radiofrequency in comparison with standard-voltage pulsed radiofrequency for the treatment of elderly patients with acute herpes zoster neuralgia.
Sixty-four elderly acute herpes zoster neuralgia patients were randomly assigned to the standard-voltage pulsed radiofrequency group (i.e., group S, 32 cases) and the high-voltage pulsed radiofrequency group (i.e., group H, 32 cases), which received the standard-voltage and high-voltage pulsed radiofrequency treatment, respectively. The doses of gabapentin and tramadol for analgesia were adjusted based on pain degree of patients. The therapeutic effectiveness were assessed using the numeric rating scale and the sleep quality scale. The doses of gabapentin and tramadol before pulsed radiofrequency and 1, 2, 4, 8, and 12 weeks after pulsed radiofrequency were measured. The incidence of clinically meaningful postherpetic neuralgia (pulsed radiofrequency) 12 weeks after pulsed radiofrequency was noted.
After pulsed radiofrequency, the numeric rating scale score and the doses of gabapentin and tramadol in group H were significantly lower than those in group S, respectively (p<0.05). The sleep quality scale score in group H was significantly higher than that in group S (p<0.05). The incidence of clinically meaningful pulsed radiofrequency in group H was significantly lower than that in group S (p<0.05).
For the treatment of elderly patients with acute herpes zoster neuralgia, when compared with the standard-voltage pulsed radiofrequency, the high-voltage pulsed radiofrequency can rapidly and steadily reduce the pain degree, improve the sleep quality, reduce the doses of anticonvulsants and analgesics, and decrease the incidence of clinically meaningful postherpetic neuralgia.
本研究旨在评估高压脉冲射频与标准电压脉冲射频治疗老年带状疱疹后神经痛的疗效。
将 64 例老年带状疱疹后神经痛患者随机分为标准电压脉冲射频组（S 组，32 例）和高压脉冲射频组（H 组，32 例），分别接受标准电压和高压脉冲射频治疗。根据患者疼痛程度调整加巴喷丁和曲马多的剂量。采用数字评分量表和睡眠质量量表评估治疗效果。测量脉冲射频前和脉冲射频后 1、2、4、8、12 周时加巴喷丁和曲马多的剂量。记录脉冲射频后 12 周时临床有意义的带状疱疹后神经痛（脉冲射频）的发生率。
脉冲射频后，H 组的数字评分量表评分、加巴喷丁和曲马多剂量均显著低于 S 组（p<0.05），H 组睡眠质量量表评分显著高于 S 组（p<0.05），H 组临床有意义的脉冲射频发生率显著低于 S 组（p<0.05）。
与标准电压脉冲射频相比，高压脉冲射频治疗老年带状疱疹后神经痛可更快、更稳定地减轻疼痛程度，改善睡眠质量，减少抗惊厥药和镇痛药的剂量，降低临床有意义的带状疱疹后神经痛的发生率。
