State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.
Adv Exp Med Biol. 2021;1325:219-237. doi: 10.1007/978-3-030-70115-4_11.
Glycosylation plays an important role in infectious diseases. Many important interactions between pathogens and hosts involve their carbohydrate structures (glycans). Glycan interactions can mediate adhesion, recognition, invasion, and immune evasion of pathogens. To date, changes in many protein N/O-linked glycosylation have been identified as biomarkers for the development of infectious diseases and cancers. In this review, we will discuss the principal findings and the roles of glycosylation of both pathogens and host cells in the context of human important infectious diseases. Understanding the role and mechanism of glycan-lectin interaction between pathogens and hosts may create a new paradigm for discovering novel glycan-based therapies that can lead to eradication or functional cure of pathogens infection.
糖基化在传染病中起着重要作用。许多病原体和宿主之间的重要相互作用都涉及到它们的碳水化合物结构（聚糖）。糖基相互作用可以介导病原体的黏附、识别、入侵和免疫逃逸。迄今为止，许多蛋白质 N/O 连接糖基化的变化已被确定为传染病和癌症发展的生物标志物。在这篇综述中，我们将讨论糖基化在人类重要传染病中病原体和宿主细胞中的主要发现和作用。了解病原体和宿主之间糖-凝集素相互作用的作用和机制可能为发现新的聚糖为基础的治疗方法创造一个新的范例，从而导致病原体感染的根除或功能治愈。
