School of Health and Medical Sciences, Edith Cowan University, Perth, Australia.
College of Basic Medical Sciences, Harbin Medical University, Harbin, China.
Adv Exp Med Biol. 2021;1325:321-339. doi: 10.1007/978-3-030-70115-4_16.
WHO defines health as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity." We coined and defined suboptimal health status (SHS) as a subclinical, reversible stage of the pre-chronic disease. SHS is a physical state between health and disease, characterized by health complaints, general weakness, chronic fatigue, and low energy levels. We have developed an instrument to measure SHS, Suboptimal Health Status Questionnaire-25 (SHSQ-25), a self-reported survey assessing five health components that has been validated in various ethnical populations. Our studies suggest that SHS is associated with the major components of cardiovascular health and the early onset of metabolic diseases. Besides subjective measure of health (SHS), glycans are conceived as objective biomarkers of SHS. Glycans are complex and branching carbohydrate moieties attached to proteins, participating in inflammatory regulation and chronic disease pathogenesis. We have been investigating the role of glycans and SHS in multiple cardiometabolic diseases in different ethnical populations (African, Chinese, and Caucasian). Here we present case studies to prove that a combination of subjective health measure (SHS) with objective health measure (glycans) represents a window of opportunity to halt or reverse the progression of chronic diseases.
世界卫生组织将健康定义为“身体、精神和社会福祉的完全状态，而不仅仅是没有疾病或虚弱”。我们创造并定义了亚健康状态（SHS），将其作为慢性疾病前的亚临床、可逆阶段。SHS 是健康和疾病之间的一种身体状态，其特征是有健康问题、全身无力、慢性疲劳和低能量水平。我们开发了一种衡量 SHS 的工具，即亚健康状态问卷-25（SHSQ-25），这是一种自我报告的调查，评估了五个健康成分，已在不同种族人群中得到验证。我们的研究表明，SHS 与心血管健康的主要成分以及代谢疾病的早期发病有关。除了主观的健康测量（SHS）之外，聚糖被认为是 SHS 的客观生物标志物。聚糖是附着在蛋白质上的复杂分支碳水化合物，参与炎症调节和慢性疾病的发病机制。我们一直在不同种族人群（非洲人、中国人和高加索人）中研究聚糖和 SHS 在多种心血管代谢疾病中的作用。在这里，我们提出了一些案例研究来证明，将主观健康测量（SHS）与客观健康测量（聚糖）相结合，代表了阻止或逆转慢性疾病进展的机会之窗。
