Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
J Neuroendocrinol. 2021 Nov;33(11):e13035. doi: 10.1111/jne.13035. Epub 2021 Sep 8.
There has been a long history of research on the effects of oxytocin on feeding behaviour. The classic-held view is that the neurohormone is anorexigenic at least in rodents, although the data for humans are not so clear cut. Likewise, a physiological role for oxytocin is disputed. Thus, although pharmacological, anatomical and physiological data suggest oxytocin may have a function in satiety signalling, this view is not supported by the latest research using the genetic recording and manipulation of oxytocin neurones. Here, we avoid a discussion of the pharmacological effects of oxytocin and examine evidence, from both sides of the argument, concerning whether the endogenous oxytocin system has a role in the regulation of normal feeding.
长期以来，人们一直在研究催产素对进食行为的影响。经典观点认为，这种神经激素至少在啮齿类动物中具有抑制食欲的作用，尽管人类的数据并不那么明确。同样，催产素的生理作用也存在争议。因此，尽管药理学、解剖学和生理学数据表明催产素可能在饱腹感信号传递中发挥作用，但使用遗传记录和操纵催产素神经元的最新研究并不支持这一观点。在这里，我们避免讨论催产素的药理作用，而是从正反两方面来探讨内源性催产素系统在调节正常进食中的作用的证据。
