看看食物摄入量和饱腹感：从人类到啮齿动物模型。

A look on food intake and satiety: from humans to rodent models.

机构信息

Center for Neuroscience and Cell Biology, and the Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.

Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. S. Carmo-Silva is with the Multidisciplinary Institute of Ageing- Portugal, University of Coimbra, Coimbra, Portugal.

出版信息

Nutr Rev. 2022 Jul 7;80(8):1942-1957. doi: 10.1093/nutrit/nuac010.

DOI:10.1093/nutrit/nuac010

PMID:35190825

Abstract

Satiety is a complex state, influenced by numerous factors that go beyond food ingestion. Satiety influences food habits and behavior, thus affecting human health. This review provides an overview of physiological mechanisms involved in satiety and of methodologies to assess food intake and satiety in both animal models and humans. The following topics are highlighted: differences between satiety and satiation; how the central nervous system regulates food intake and satiety; the impact of different macronutrients on satiety; and how the manipulation of food composition might influence overall satiety. Bringing together knowledge on this myriad of satiety mechanisms and how we can study them is useful to better understand and control obesity and other eating disorders.

摘要

饱腹感是一种复杂的状态，受到许多因素的影响，这些因素超出了食物摄入的范畴。饱腹感影响饮食习惯和行为，从而影响人类健康。本文综述了饱腹感涉及的生理机制和评估动物模型和人类食物摄入量和饱腹感的方法。本文强调了以下几个方面：饱腹感和饱足感之间的区别；中枢神经系统如何调节食物摄入和饱腹感；不同宏量营养素对饱腹感的影响；以及食物成分的操纵如何影响整体饱腹感。汇集关于这种饱腹感机制的知识，以及我们如何研究它们，对于更好地理解和控制肥胖和其他饮食失调症是有用的。