Naples James G, Soda Drew, Rahman Kahlil, Ruckenstein Michael J, Parham Kourosh
Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Otolaryngology-Head and Neck Surgery, Boston, Massachusetts, USA.
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
Ear Hear. 2022 Mar/Apr;43(2):699-702. doi: 10.1097/AUD.0000000000001123.
To evaluate the role for prestin and otolin-1 as biomarkers for differentiating Meniere's disease (MD) from vestibular migraine (VM).
It is a cross-sectional, cohort study.
There were 19 MD and 11 VM patients. In the 19 MD patients, the mean prestin level was 2.33 ng/ml compared to 0.64 ng/ml in VM patients (p = 0.238). Otolin-1 levels in MD patients were 109.67 pg/ml, while in VM patients, otolin-1 levels were 30.9 pg/ml (p = 0.102). In MD patients, prestin levels were correlated with word recognition scores, being strongest when prestin >2 ng/ml (rho = 0.9; p = 0.019).
Prestin and otolin-1 levels differed between MD patients relative to VM patients. The relationship between prestin and word recognition scores in MD suggests that there may be a role for prestin as a marker for inner ear function, but its role in differentiating MD from VM remains to be elucidated.
评估 prestin 和 otolin-1 作为鉴别梅尼埃病（MD）和前庭性偏头痛（VM）生物标志物的作用。
这是一项横断面队列研究。
有 19 例 MD 患者和 11 例 VM 患者。在 19 例 MD 患者中，prestin 的平均水平为 2.33 ng/ml，而 VM 患者为 0.64 ng/ml（p = 0.238）。MD 患者的 otolin-1 水平为 109.67 pg/ml，而 VM 患者的 otolin-1 水平为 30.9 pg/ml（p = 0.102）。在 MD 患者中，prestin 水平与单词识别分数相关，当 prestin >2 ng/ml 时相关性最强（rho = 0.9；p = 0.019）。
MD 患者与 VM 患者之间的 prestin 和 otolin-1 水平存在差异。MD 中 prestin 与单词识别分数之间的关系表明，prestin 可能作为内耳功能的标志物，但它在区分 MD 和 VM 中的作用仍有待阐明。
