World Health Organisation Collaborating Centre for STI and AMR, Sydney and Neisseria Reference Laboratory, Department of Microbiology, New South Wales Health Pathology, The Prince of Wales Hospital, Randwick, 2031, NSW Australia.
School of Medical Sciences, Faculty of Medicine, The University of New South Wales, NSW, 2052 Australia.
Commun Dis Intell (2018). 2021 Aug 30;45. doi: 10.33321/cdi.2021.45.46.
Invasive meningococcal disease (IMD) is a notifiable disease in Australia, and both probable and laboratory-confirmed cases of IMD are reported to the National Notifiable Diseases Surveillance System (NNDSS). In 2020, there were 90 notifications of IMD, the lowest number documented since records began in the NNDSS in 1991. Of these, 97% (87/90) were laboratory-confirmed cases, with 70% (61/87) confirmed by bacterial culture and 30% (26/87) by nucleic acid amplification testing. The serogroup was determined for 85/87 laboratory-confirmed cases of IMD: serogroup B (MenB) accounted for 64% of infections (54/85); MenW for 19% (16/85); MenY for 16% (14/85); and MenC 1.2% (1/85). Fine typing was available on 60/85 (71%) of cases with serogroup determined; of the typed MenW, all were PorA antigen type P1.5,2 and sequence type 11, the hypervirulent strain reported in recent outbreaks in Australia and overseas. The primary peaks of IMD notifications in Australia in 2020 were observed in infants less than 1 year (16/87, 18%) and in adults aged 45-64 years (14/87, 16%). MenB infections predominated in those aged less than 5 years and 15-19 years; MenW and MenY infections predominated in those aged 45 years or more. All 61 IMD isolates were tested for antimicrobial susceptibility: none were penicillin resistant; however, 56/61 (92%) had decreased susceptibility to penicillin. All isolates were susceptible to ceftriaxone, ciprofloxacin and rifampicin.
侵袭性脑膜炎奈瑟菌病(IMD)是澳大利亚的一种法定报告传染病,疑似和实验室确诊的 IMD 病例均需向国家法定传染病监测系统(NNDSS)报告。2020 年,共报告了 90 例 IMD 病例,这是自 NNDSS 于 1991 年开始记录以来报告病例数最少的一年。其中,97%(87/90)为实验室确诊病例,70%(61/87)通过细菌培养确诊,30%(26/87)通过核酸扩增试验确诊。对 87 例实验室确诊的 IMD 病例进行了血清型分析:B 群(MenB)血清型占 64%(54/85);W 群(MenW)占 19%(16/85);Y 群(MenY)占 16%(14/85);C 群 1.2%(1/85)。对 85 例确定血清型的病例进行了精细分型;在分型的 MenW 中,所有菌株的 PorA 抗原型均为 P1.5,2,序列型为 11,这是澳大利亚和海外最近暴发疫情中报告的高毒力菌株。2020 年澳大利亚 IMD 病例报告的主要高峰期出现在 1 岁以下婴儿(16/87,18%)和 45-64 岁成年人(14/87,16%)。MenB 感染多见于 5 岁以下和 15-19 岁儿童;MenW 和 MenY 感染多见于 45 岁及以上人群。对所有 61 例 IMD 分离株进行了抗菌药物敏感性检测:无青霉素耐药株;然而,61 株中有 56 株(92%)对青霉素的敏感性降低。所有分离株对头孢曲松、环丙沙星和利福平均敏感。