Thulutha Beni Essa Primary Health Care Center, Saudi Arabia Ministry of Health, Al Qunfudhah, Makkah, Saudi Arabia
Primary Health Care Center, Saudi Arabia Ministry of Health, Al Lith, Makkah, Saudi Arabia.
BMJ Open. 2021 Sep 8;11(9):e047980. doi: 10.1136/bmjopen-2020-047980.
Peripheral arterial disease (PAD) is the third leading atherosclerotic arterial disease. There is evidence that there is a high variation in the quality and recommendations of clinical practice guidelines for PAD, leading to the possibility of confusion among clinicians and patients. This study aims to conduct a quality assessment and comparative analysis of the clinical practice guidelines on PAD written between 2010 and 2020.
We aim to perform a systematic review of clinical practice guidelines written between 2010 and 2020. A search for guidelines will be conducted through medical databases Scope, Pubmed, TRIP, Guideline Clearinghouses and specialist international organisations' specific websites. Guidelines that meet the inclusion criteria will be extracted from the search result. The Appraisal of Guidelines for Research and Evaluation II (AGREE-II instrument) will assess the quality of the selected guidelines. The recommendations, level of evidence and other relevant information will be extracted in a datasheet for qualitative analysis. The score for each guideline's quality will be represented using charts and central tendency measures for comparison. The summary of recommendations will also be represented in tables for easy comparison for similarities and variations across sections. Finally, the level of evidence on which the recommendations are based will also be noted along with other significant characteristics such as the authors' financial relationship to the biomedical community. We aim to point out deficiencies present in current guidelines and elucidate areas where recommendations are made with low-level evidence. The results will enable the scientific community to design future research to fill in PAD management knowledge gaps.
No ethical approval was sought. Dissemination will be via journal articles and conference presentations.
CRD42020219176.
外周动脉疾病（PAD）是第三大动脉粥样硬化性动脉疾病。有证据表明，PAD 的临床实践指南在质量和建议方面存在很大差异，这导致临床医生和患者之间可能存在混淆。本研究旨在对外周动脉疾病临床实践指南进行质量评估和比较分析，这些指南是在 2010 年至 2020 年期间撰写的。
我们旨在对 2010 年至 2020 年期间撰写的临床实践指南进行系统回顾。将通过 Scope、Pubmed、TRIP、指南清理中心和专门的国际组织特定网站等医学数据库进行指南搜索。从搜索结果中提取符合纳入标准的指南。将使用评估研究和评估指南 II（AGREE-II 工具）评估所选指南的质量。将从指南中提取建议、证据水平和其他相关信息，并在数据表中进行定性分析。将使用图表和中心趋势度量来表示每个指南质量的得分，以便进行比较。还将以表格形式表示建议的摘要，以便轻松比较各部分之间的相似点和差异。最后，还将注意建议所依据的证据水平以及其他重要特征，例如作者与生物医学界的财务关系。我们旨在指出当前指南中存在的缺陷，并阐明在哪些领域基于低水平证据提出了建议。研究结果将使科学界能够设计未来的研究来填补 PAD 管理知识空白。
未寻求伦理批准。传播将通过期刊文章和会议演示进行。
PROSPERO 注册号：CRD42020219176。
