Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India.
Department of Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India.
World J Gastroenterol. 2021 Aug 14;27(30):4939-4962. doi: 10.3748/wjg.v27.i30.4939.
Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes mellitus is considered as an important risk factor for its development. This risk can be modified by the use of certain antidiabetic medications. On the other hand, new-onset diabetes can signal towards an underlying PC in the elderly population. Recently, several attempts have been made to develop an effective clinical tool for PC screening using a combination of history of new-onset diabetes and several other clinical and biochemical markers. On the contrary, diabetes affects the survival after treatment for PC. We describe this intimate and complex two-way relationship of diabetes and PC in this review by exploring the underlying pathogenesis.
胰腺癌（PC）常伴有不良预后。长期存在的糖尿病被认为是其发展的一个重要危险因素。这种风险可以通过使用某些抗糖尿病药物来改变。另一方面，在老年人群中，新发糖尿病可能提示存在潜在的 PC。最近，人们尝试使用新发糖尿病病史和其他一些临床及生化标志物的组合来开发一种有效的 PC 筛查临床工具。相反，糖尿病会影响 PC 治疗后的生存。我们通过探讨潜在的发病机制，在本综述中描述了糖尿病和 PC 之间这种密切而复杂的双向关系。
