From the Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Pancreas. 2014 Oct;43(7):1014-7. doi: 10.1097/MPA.0000000000000158.
The aim of this study was to examine the association of risk factors including diabetes mellitus (DM) with the age of onset in Japanese pancreatic cancer (PC) patients.
We retrospectively reviewed 688 PC patients diagnosed at our institute. We analyzed the association between the age of onset of PC and the following variables: sex, smoking, alcohol, DM, and a family history of cancer especially PC.
The mean age of PC diagnosis was 67.6 years. The onset of PC occurred earlier in current smokers (63.6 years old, P < 0.001) compared with past smokers (69.5 years old) and never smokers (68.6 years old). Patients with long-standing DM (>2 years) were older (70.5 years, P < 0.001) when diagnosed with PC than patients with new-onset DM (within 2 years) (66.9 years old) and patients without DM (66.7 years old). In the multivariate analysis, current smokers and a family history of cancer other than PC were associated with earlier onset. Conversely, long-standing DM was associated with later onset.
In Japanese PC patients, current smokers and a family history of cancer other than PC were associated with a younger age of onset. Conversely, long-standing DM was associated with a later onset.
本研究旨在探讨包括糖尿病（DM）在内的危险因素与日本胰腺癌（PC）患者发病年龄的关系。
我们回顾性分析了在我院诊断的 688 例 PC 患者。我们分析了 PC 发病年龄与以下变量之间的关系：性别、吸烟、饮酒、DM 和癌症家族史（特别是 PC）。
PC 诊断的平均年龄为 67.6 岁。与既往吸烟者（69.5 岁）和不吸烟者（68.6 岁）相比，目前吸烟者（63.6 岁）PC 的发病年龄更早（P<0.001）。与新发 DM（2 年内）患者（66.9 岁）和无 DM 患者（66.7 岁）相比，DM 病史较长（>2 年）的患者诊断为 PC 时年龄更大（70.5 岁，P<0.001）。在多变量分析中，目前吸烟和除 PC 以外的癌症家族史与发病年龄较早相关。相反，长期 DM 与发病年龄较晚相关。
在日本 PC 患者中，目前吸烟者和除 PC 以外的癌症家族史与发病年龄较早相关。相反，长期 DM 与发病年龄较晚相关。
