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胆囊收缩素在心肌肥厚发展中的表达。

Cholecystokinin Expression in the Development of Myocardial Hypertrophy.

机构信息

Department of Cardiology, Harbin Medical University Fourth Hospital, Harbin 150086, China.

Department of Critical Care Medicine, Affiliated Qiqihar Hospital, Southern Medical University (The First Hospital of Qiqihar), Qiqihar 161005, China.

出版信息

Scanning. 2021 Aug 21;2021:8231559. doi: 10.1155/2021/8231559. eCollection 2021.

DOI:10.1155/2021/8231559
PMID:34497680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8405328/
Abstract

BACKGROUND

Expression of cholecystokinin is found in myocardial tissues as a gastrointestinal hormone and may be involved in cardiovascular regulation. However, it is unclear whether there is an increase in cholecystokinin expression in myocardial hypertrophy progression induced by abdominal aortic constriction. The study is aimed at exploring the relationship between cholecystokinin expression and myocardial hypertrophy.

METHODS

We randomly divided the 70 Sprague-Dawley rats into two groups: the sham operation group and the abdominal aortic constriction group. The hearts of rats were measured by echocardiography, and myocardial tissues and blood were collected at 4 weeks, 8 weeks, and 12 weeks after surgery. Morphological changes were assessed by microscopy. The cholecystokinin expression was evaluated by immunochemistry, Western blotting, quantitative real-time polymerase chain reaction, and enzyme-linked immunosorbent assay.

RESULTS

The relative protein levels of cholecystokinin were significantly increased in the abdominal aortic constriction groups compared with the corresponding sham operation groups at 8 weeks and 12 weeks. The cholecystokinin mRNA in the abdominal aortic constriction groups was significantly higher than the time-matched sham operation groups. Changes in the left ventricular wall thickness were positively correlated with the relative protein levels of cholecystokinin and the mRNA of cholecystokinin.

CONCLUSIONS

The development of myocardial hypertrophy can affect the cholecystokinin expression of myocardial tissues.

摘要

背景

胆囊收缩素作为一种胃肠激素存在于心肌组织中，可能参与心血管调节。然而，腹主动脉缩窄引起的心肌肥厚进展中胆囊收缩素表达是否增加尚不清楚。本研究旨在探讨胆囊收缩素表达与心肌肥厚的关系。

方法

我们将 70 只 Sprague-Dawley 大鼠随机分为两组：假手术组和腹主动脉缩窄组。术后 4 周、8 周和 12 周，通过超声心动图测量大鼠心脏，采集心肌组织和血液。通过显微镜评估形态变化。通过免疫化学、Western blot、实时定量聚合酶链反应和酶联免疫吸附试验评估胆囊收缩素表达。

结果

与相应的假手术组相比，腹主动脉缩窄组在 8 周和 12 周时胆囊收缩素的相对蛋白水平显著升高。腹主动脉缩窄组的胆囊收缩素 mRNA 明显高于相应的假手术组。左心室壁厚度的变化与胆囊收缩素的相对蛋白水平和胆囊收缩素 mRNA 呈正相关。

结论

心肌肥厚的发展会影响心肌组织中胆囊收缩素的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/5f5eb29d9281/SCANNING2021-8231559.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/35c608faca5d/SCANNING2021-8231559.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/5a291583ce28/SCANNING2021-8231559.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/55adb2fc0626/SCANNING2021-8231559.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/06e3e498a7b4/SCANNING2021-8231559.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/5f5eb29d9281/SCANNING2021-8231559.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/35c608faca5d/SCANNING2021-8231559.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/5a291583ce28/SCANNING2021-8231559.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/55adb2fc0626/SCANNING2021-8231559.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/06e3e498a7b4/SCANNING2021-8231559.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e376/8405328/5f5eb29d9281/SCANNING2021-8231559.005.jpg

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