Nott D M, Grime J S, Yates J, O'Driscoll M P, Baxter J N, Cooke T G, Jenkins S A
University Department of Surgery and Nuclear Medicine, Royal Liverpool Hospital, UK.
Nucl Med Commun. 1987 Dec;8(12):990-4. doi: 10.1097/00006231-198712000-00007.
The hepatic perfusion index (HPI) is an indicator of the relative hepatic arterial to total liver blood flow as measured by dynamic flow scintigraphy. Hitherto, accurate assessment of the HPI in small animals has not been possible because of methodological difficulties. A reproducible method for measuring the HPI by dynamic scintigraphy in rats is described using a rapid intraventricular bolus administration of 0.04 ml 99Tcm sulphur colloid. There was no significant difference between the HPI determined by dynamic scintigraphy and and that calculated from absolute measurements of hepatic arterial and total liver blood flow. These results indicate that the HPI derived by dynamic scintigraphy in the rat is a true estimate of the ratio of the hepatic arterial to total liver blood flow.
肝脏灌注指数（HPI）是通过动态血流闪烁显像测量的肝动脉血流与全肝血流的相对指标。迄今为止，由于方法上的困难，尚无法在小动物中准确评估HPI。本文描述了一种通过动态闪烁显像在大鼠中测量HPI的可重复方法，即通过快速脑室内推注0.04 ml 99锝硫胶体。动态闪烁显像测定的HPI与根据肝动脉和全肝血流绝对测量值计算得出的HPI之间无显著差异。这些结果表明，通过动态闪烁显像在大鼠中得出的HPI是肝动脉血流与全肝血流比值的真实估计值。
