Nott D M, Grime J S, Yates J, Day D W, Baxter J N, Jenkins S A, Cooke T G
University Department of Surgery, Royal Liverpool Hospital, UK.
Nucl Med Commun. 1987 Dec;8(12):995-1000. doi: 10.1097/00006231-198712000-00008.
Micrometastases were induced in Fisher rats using an intraportal inoculation of 0.2 ml of 8 x 10(7) Walker carcinosarcoma cells. A control group received normal saline. The hepatic perfusion index (HPI) was measured during the growth and development of micrometastases. The HPI at 4 days (0.51 +/- 0.008) and at 6 days (0.65 +/- 0.16) was significantly raised when compared to controls (0.31 +/- 0.07) and at 2 days after inoculation (0.31 +/- 0.06). Hepatic artery flow did not change throughout the study period. However, portal venous inflow was decreased significantly at 4 and 6 days (0.57 +/- 0.16 and 0.55 +/- 0.11) when compared to controls (0.96 +/- 0.34). These results indicate that the change in the hepatic perfusion index is related to a decrease in portal venous inflow. The decrease in portal venous inflow could be a mechanical effect of the micrometastases on intrahepatic blood flow or to increased arteriovenous shunting.
通过门静脉内接种0.2毫升含8×10⁷个Walker癌肉瘤细胞的悬液，在Fisher大鼠体内诱导微转移。对照组注射生理盐水。在微转移的生长和发展过程中测量肝脏灌注指数（HPI）。与对照组（0.31±0.07）及接种后2天（0.31±0.06）相比，接种后4天（0.51±0.008）和6天（0.65±0.16）时HPI显著升高。在整个研究期间肝动脉血流没有变化。然而，与对照组（0.96±0.34）相比，在4天和6天时门静脉流入量显著减少（0.57±0.16和0.55±0.11）。这些结果表明肝脏灌注指数的变化与门静脉流入量的减少有关。门静脉流入量的减少可能是微转移对肝内血流的机械作用或动静脉分流增加所致。
