Tohi Yoichiro, Kataoka Koki, Miyai Yumi, Kaku Yo, Dainichi Teruki, Haba Reiji, Tsunemori Hiroyuki, Sugimoto Mikio
Department of Urology Faculty of Medicine Kagawa University Kagawa Japan.
Department of Dermatology Faculty of Medicine Kagawa University Kagawa Japan.
IJU Case Rep. 2021 Jun 27;4(5):299-302. doi: 10.1002/iju5.12331. eCollection 2021 Sep.
Apalutamide-associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding.
Case 1: a 71-year-old man with metastatic castration-sensitive prostate cancer developed a skin rash after 70 days of apalutamide treatment. Case 2: a 71-year-old man with non-metastatic castration-resistant prostate cancer developed a skin rash after 71 days of apalutamide treatment. In both cases, the skin rash presented as a slightly exudative erythema. The histology showed spongiosis of the epidermis and perivascular and interstitial infiltration of lymphocytes and eosinophils in the upper dermis without necrotic keratinocytes.
Apalutamide-induced skin rashes can involve an eczematous reaction clinically and histologically.
与阿帕鲁胺相关的皮疹在日本人群中是比全球人群中更常见的不良事件。然而，其机制仍不清楚，有限的组织病理学信息阻碍了进一步的了解。
病例1：一名71岁转移性去势敏感性前列腺癌男性在接受阿帕鲁胺治疗70天后出现皮疹。病例2：一名71岁非转移性去势抵抗性前列腺癌男性在接受阿帕鲁胺治疗71天后出现皮疹。在这两个病例中，皮疹均表现为轻度渗出性红斑。组织学显示表皮海绵形成，真皮上层血管周围和间质有淋巴细胞和嗜酸性粒细胞浸润，无坏死角质形成细胞。
阿帕鲁胺引起的皮疹在临床和组织学上可涉及湿疹样反应。
