Hamid S, Beg A E
Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Pakistan.
Pol J Pharmacol Pharm. 1987 Jul-Aug;39(4):337-42.
The influence of time and different ethnic diets on relative bioavailability and pharmacokinetics of orally administered ampicillin was studied in healthy Pakistani subjects. The bioavailability of ampicillin was determined using the plasma levels which were measured microbiologically. Plasma levels were analyzed, assuming a one-compartment linear model with first order absorption. Different types of Pakistani diets ingested immediately before dosing reduced plasma levels to an almost similar extent, while different results were found upon changing the time of drug administration with respect to the food intake. The study reveals that, for maximum absorption, ampicillin should be given on empty stomach and at least 1.5 h before the meal.
在健康的巴基斯坦受试者中研究了时间和不同民族饮食对口服氨苄西林相对生物利用度和药代动力学的影响。使用微生物学方法测定的血浆水平来确定氨苄西林的生物利用度。假设为具有一级吸收的单室线性模型对血浆水平进行分析。给药前立即摄入的不同类型的巴基斯坦饮食会使血浆水平降低到几乎相同的程度，而在改变给药时间与进食时间的关系时则发现了不同的结果。该研究表明，为了实现最大吸收，氨苄西林应空腹给药且至少在饭前1.5小时服用。
