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In classical Hodgkin lymphoma the combination of the CCR5 antagonist maraviroc with trabectedin synergizes, enhances DNA damage and decreases three-dimensional tumor-stroma heterospheroid viability.

作者信息

Casagrande Naike, Borghese Cinzia, Aldinucci Donatella

机构信息

Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano (PN).

出版信息

Haematologica. 2022 Jan 1;107(1):287-291. doi: 10.3324/haematol.2021.279389.

DOI:10.3324/haematol.2021.279389
PMID:34498447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8719077/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/420d0511244d/107287.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/5d97011310c3/107287.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/68d66e72eb38/107287.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/420d0511244d/107287.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/5d97011310c3/107287.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/68d66e72eb38/107287.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b36/8719077/420d0511244d/107287.fig3.jpg

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本文引用的文献

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Trabectedin overcomes doxorubicin-resistance, counteracts tumor-immunosuppressive reprogramming of monocytes and decreases xenograft growth in Hodgkin lymphoma.曲贝替定克服多柔比星耐药性,逆转单核细胞的肿瘤免疫抑制重编程,并降低霍奇金淋巴瘤的异种移植瘤生长。
Cancer Lett. 2021 Mar 1;500:182-193. doi: 10.1016/j.canlet.2020.12.015. Epub 2020 Dec 14.
2
Hodgkin lymphoma.霍奇金淋巴瘤。
Nat Rev Dis Primers. 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6.
3
The CCL5/CCR5 Axis in Cancer Progression.癌症进展中的CCL5/CCR5轴
The Medium Obtained from the Culture of Hodgkin Lymphoma Cells Affects the Biophysical Characteristics of a Fibroblast Cell Model.
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Bioengineering (Basel). 2023 Feb 3;10(2):197. doi: 10.3390/bioengineering10020197.
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HIV Infection, Chromosome Instability, and Micronucleus Formation.人类免疫缺陷病毒感染、染色体不稳定性和微核形成。
Viruses. 2023 Jan 4;15(1):155. doi: 10.3390/v15010155.
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Promising drugs and treatment options for pediatric and adolescent patients with Hodgkin lymphoma.针对患有霍奇金淋巴瘤的儿童和青少年患者的有前景的药物及治疗选择。
Front Cell Dev Biol. 2022 Nov 24;10:965803. doi: 10.3389/fcell.2022.965803. eCollection 2022.
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